Issue 82, 2024

Targeting sub-cellular organelles for boosting precision photodynamic therapy

Abstract

Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have received increasing interest due to their precise accumulation and ability to trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, and prevents recurrence. In this review, recent advances and representative photosensitizers used in targeted photodynamic therapy on organelles, specifically including the endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, and lysosomes, have been comprehensively reviewed with a focus on organelle structure and organelle-mediated cell death signalling pathways. Furthermore, a perspective on future research and potential challenges in precision photodynamic therapy has been presented at the end.

Graphical abstract: Targeting sub-cellular organelles for boosting precision photodynamic therapy

Article information

Article type
Highlight
Submitted
03 jun 2024
Accepted
10 sep 2024
First published
13 sep 2024

Chem. Commun., 2024,60, 11610-11624

Targeting sub-cellular organelles for boosting precision photodynamic therapy

G. S. Attar, M. Kumar and V. Bhalla, Chem. Commun., 2024, 60, 11610 DOI: 10.1039/D4CC02702G

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