Issue 3, 2023

In situ growth of metal–organic frameworks in nanochannels for highly sensitive microcystin-LR detection

Abstract

Microcystin-LR (MC-LR) is a known hepatotoxin that is the most abundant and potent cyanobacterial toxin. The development of a strategy for sensitive MC-LR detection is highly demanded. In this work, a novel solid-state nanochannel-based sensing system was constructed by in situ growth of metal–organic frameworks (MOFs) on anodic aluminum oxide (AAO) nanochannels and modification with an MC-LR-specific aptamer as a probe. The MOF was employed to reduce the effective diameter of the nanochannels and provided abundant functional active sites for the probes. As a result, highly sensitive MC-LR detection was realized with the limit of detection reaching 0.004 ng mL−1. Compared to the nanochannels without MOF modification, the sensitivity has been significantly improved, by around 10 000-fold. Furthermore, highly reliable detection of MC-LR in various water samples was also achieved, with a relative standard deviation of less than 5.46% and recovery between 93.90% and 106.73%. This strategy provides significant insight for practical applications of nanochannel-based sensing systems, including environmental contaminant detection, food analysis, and medical analysis.

Graphical abstract: In situ growth of metal–organic frameworks in nanochannels for highly sensitive microcystin-LR detection

Supplementary files

Article information

Article type
Paper
Submitted
13 dec 2022
Accepted
01 feb 2023
First published
06 feb 2023

Environ. Sci.: Nano, 2023,10, 834-842

In situ growth of metal–organic frameworks in nanochannels for highly sensitive microcystin-LR detection

W. Zhang, Y. Tu, X. Wang, Y. Huang and F. Xia, Environ. Sci.: Nano, 2023, 10, 834 DOI: 10.1039/D2EN01119K

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