Issue 23, 2022

Ultra-thin silica shell-guarded nanoflares for high-fidelity live cell miRNA-21 imaging by fully avoiding the interference of biothiols

Abstract

We successfully constructed a new class of nanoflares based on ultra-thin silica-coated gold nanoparticles (Au@SiO2) with the covalent binding of nucleic acids, which demonstrated more resistance to biothiols than that exhibited in the traditional Au–S binding strategy, for imaging the target miRNA-21 with high fidelity in living cells.

Graphical abstract: Ultra-thin silica shell-guarded nanoflares for high-fidelity live cell miRNA-21 imaging by fully avoiding the interference of biothiols

Supplementary files

Article information

Article type
Communication
Submitted
31 aug 2022
Accepted
06 nov 2022
First published
07 nov 2022

Analyst, 2022,147, 5269-5273

Ultra-thin silica shell-guarded nanoflares for high-fidelity live cell miRNA-21 imaging by fully avoiding the interference of biothiols

Y. Luo, Z. Wang, J. Li, W. Yi, K. Yang, C. Ou, L. Deng and D. He, Analyst, 2022, 147, 5269 DOI: 10.1039/D2AN01441F

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