Issue 18, 2019

Towards precision medicine: the role and potential of protein and peptide microarrays

Abstract

Although the traditional strategy of developing general medical treatments for heterogeneous patient populations has a well-established track record, the acknowledgment that one-size-does-not-fit-all is pushing health-care to enter a new era of tailored interventions. The advent of precision medicine is fueled by the high-throughput analysis of individual DNA variants and mRNA expression profiles. However, due to the role of proteins in providing a more direct view of disease states than genomics alone, the ability to comprehensively analyze protein alterations and post translational modifications (PTMs) is a necessary step to unravel disease mechanisms, develop novel biomarkers and targeted therapies. Protein and peptide microarrays can play a major role in this frame, due to high-throughput, low sample consumption and wide applicability. Here, their current role and potentialities are discussed through the review of some promising applications in the fields of PTMs analysis, enzyme screening, high-content immune-profiling and the phenotyping of extracellular vesicles.

Graphical abstract: Towards precision medicine: the role and potential of protein and peptide microarrays

Article information

Article type
Critical Review
Submitted
21 jun 2019
Accepted
27 jul 2019
First published
31 jul 2019

Analyst, 2019,144, 5353-5367

Towards precision medicine: the role and potential of protein and peptide microarrays

D. Brambilla, M. Chiari, A. Gori and M. Cretich, Analyst, 2019, 144, 5353 DOI: 10.1039/C9AN01142K

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