Issue 42, 2017

Copper-catalyzed remote (δ) C(sp3)–H bond amination: a practical strategy to construct pyrrolidine derivatives

Abstract

We report a copper-catalyzed remote C(sp3)–H bond amination reaction that converts acyclic amines to pyrrolidines. This reaction occurs selectively at the carbon δ to the amine functionality. Primary, secondary and tertiary C–H bonds are all suitable for the amination reactions in the presence of an inexpensive and commercially available copper catalyst.

Graphical abstract: Copper-catalyzed remote (δ) C(sp3)–H bond amination: a practical strategy to construct pyrrolidine derivatives

Supplementary files

Article information

Article type
Communication
Submitted
05 apr 2017
Accepted
04 mei 2017
First published
04 mei 2017

Chem. Commun., 2017,53, 5744-5747

Copper-catalyzed remote (δ) C(sp3)–H bond amination: a practical strategy to construct pyrrolidine derivatives

D. Meng, Y. Tang, J. Wei, X. Shi and M. Yang, Chem. Commun., 2017, 53, 5744 DOI: 10.1039/C7CC02624B

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