Issue 5, 2015

Disruption of zinc and copper interactions with Aβ(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?

Abstract

Disruptions of biometal–Aβ(1–40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg−1, showing potential as an anti-Alzheimer's drug.

Graphical abstract: Disruption of zinc and copper interactions with Aβ(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?

Supplementary files

Article information

Article type
Communication
Submitted
03 jan 2015
Accepted
01 apr 2015
First published
01 apr 2015

Metallomics, 2015,7, 743-747

Author version available

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