A photocatalytic radical-mediated strategy has been developed for the 1,5-hydrogen atom transfer (1,5-HAT)/alkenylation of hydroxamides with enamides, enabling the efficient synthesis of trisubstituted enamides in moderate to good yields.
The synthesis of various difluoroamidosulfonylated quinolines was achieved via an EDA complex-mediated radical tandem bicyclization of N-propargyl aromatic amines with N-allylbromodifluoroacetamides and DABSO under photocatalyst-free conditions.
A photocatalytic Heck-type alkylation of enamides with N-trifluoroethyl hydroxylamine reagents was developed to synthesize amido-substituted (E)-α-trifluoromethyl allylamines.
A photocatalytic γ-C(sp3)–H vinylation of hydroxamic acid derivatives with enamides was developed via 1,5-hydrogen atom transfer and cross-dehydrogenative coupling reactions.
An N-heterocyclic carbene catalyzed radical tandem cyclization reaction of N-allylbromodifluoroacetamides and aldehydes has been developed. This method provides a protocol for synthesizing α,α-difluoro-γ-lactam derivatives in moderate to good results (27 examples, up to 88% yield, 10 : 1 d.r.).