This review analyses recent advances and strategies employed in the Pd-AAA of nucleophilic prochiral heterocycles. Each section is focused on a specific heterocycle, where optimisation data and reaction scope have been carefully analysed.
Asymmetric organocatalysis has acquired a prominent place in modern synthesis of noncanonical α-amino acids (ncAAs), valuable structural elements in organic synthesis, chemical biology, and medicine.
A unified and controlled cyclization reaction between azlactone and O-acetyl oxime is accomplished.
Contemporary approaches for the synthesis of non-proteinogenic metal-binding amino acids are reviewed.
Macromolecular design via the interchange of xanthate polymerization of 2-vinyl-4,4-dimethylazlactone is studied under industrially viable conditions to access a reactive polymer platform.