Florian Hubrich
Nat. Prod. Rep., 2026, Advance Article
Abstract
This review highlights advances in the field of amino acid and peptide prenyltransferases, underscoring their value for chemoenzymatic peptide late-stage functionalization and drug development and showcasing their scope, promiscuity and engineering.
Evan T. Miller, Oleg V. Tsodikov and Sylvie Garneau-Tsodikova
Nat. Prod. Rep., 2024,41, 113-147
Abstract
This review unpacks the accumulated knowledge of the structural bases of the unique properties and capabilities of DMATS-type prenyltransferases (PTs) that make them promising biocatalysts.
Christopher T. Walsh
Nat. Prod. Rep., 2023,40, 326-386
Abstract
Secondary metabolites are assembled by drawing off and committing some of the flux of primary metabolic building blocks to sets of enzymes that tailor the maturing scaffold.
Yuya Kakumu, Ayesha Ahmed Chaudhri and Eric J. N. Helfrich
Nat. Prod. Rep., 2025,42, 501-539
Abstract
This review explores recent insights into the roles and enzymatic mechanisms of canonical and non-canonical tailoring enzymes in shaping and modifying terpene hydrocarbon scaffolds during bacterial terpene biosynthesis.
Mamoalosi A. Selepe, Siyanda T. Mthembu and Molahlehi S. Sonopo
Nat. Prod. Rep., 2025,42, 540-591
From themed collection:
Emerging Investigator Review series
Abstract
The review is on synthesis of different classes of isoflavonoids that include isoflavones, isoflavanones, isoflavans, isoflavenes, pterocarpans, rotenoids, coumaronochromones, and coumestans.