Methicillin-resistant Staphylococcus aureus (MRSA), one of the most common multidrug-resistant (MDR) bacterial strains, has severely threatened global healthcare for decades due to its high morbidity and mortality rates.
This review explores recent insights into the roles and enzymatic mechanisms of canonical and non-canonical tailoring enzymes in shaping and modifying terpene hydrocarbon scaffolds during bacterial terpene biosynthesis.
Halogenases and dehalogenases are ubiquitous biocatalysts that mediate halogen incorporation and removal. Synthetic biology is reshaping their catalytic landscapes to unlock new functions and applications.
This review offers an overview of the canonical and noncanonical class II terpene cyclases, including sesquiterpene, diterpene, triterpene, and meroterpenoid cyclases. It delves into their sequences, structures, mechanisms, and engineering studies.
Biocatalysis has ascended as a defining force in contemporary total synthesis, furnishing catalytic modalities that deliver molecular complexity with unparalleled chemo-, regio-, and stereo-control.