We reported a direct simple trifluoromethylthiolation reaction of various terminal alkynes using a new hypervalent trifluoromethylthio-iodine(III) reagent TFTI in a fluorinated alcohol, either hexafluoro-2-propanol or perfluoro-tert-butanol.
This review comprehensively summarizes the dichalcogenative functionalization of unsaturated compounds over the past decade. The scopes, limitations and detailed reaction mechanisms are also discussed.
Using S-trifluoromethyl thioesters as bifunctional reagents, we developed photoredox/copper dual-catalyzed 1,2-acyl-trifluoromethylthiolation of alkenes and 1,4-acyl-trifluoromethylthiolation of 1,3-enynes.
The mechanism of the Ni-catalysed trifluoromethylthiolation of aryl chlorides using AgSCF3 is studied herein.
Visible-light-driven chemo-/regioselective diversification using TTST's dual radical reactivity for CF3/SCF3-functionalized products.