Spiropyrrolidines were synthesized in good yields by cycloaddition protocol, these compounds showed potent cholinesterase inhibitory activities. Experimental in vitr o findings are consistent with docking and molecular dynamics simulations.
4-Hydroxyacetophenone derivatives were synthesized and characterized. These compounds exhibited promising cholinesterase inhibition, supported by docking and DFT studies that revealed strong binding interactions and favorable electronic properties.
The first asymmetric total synthesis of naturally occurring atropodiastereomers of Amaryllidaceae alkaloids, such as narcipavlines A (1a) and B (1b) and narcikachnines A (2a) and B (2b), sharing a cis-dihydrobenzofuran structure is reported.
In current research, two functional components, i.e., hydrazone and bisphenol sulfide were combined to get useful supramolecules in medicinal chemistry.
Biocatalysis has ascended as a defining force in contemporary total synthesis, furnishing catalytic modalities that deliver molecular complexity with unparalleled chemo-, regio-, and stereo-control.