Herein, we report a t-BuONa-promoted method for the site-selective silylation of 2H-indazoles.
Indazoles as privileged scaffolds; synthetic strategies; clinical trial compounds; biological activities: anti-tubercular, antifungal, antibacterial, antileishmanial, anti-Parkinson's, anti-inflammatory, antidiabetic, and anticancer.
The electrochemical C3 acyloxylation reactions of 2H-indazoles with carboxylic acids in the presence of K2CO3 were successfully developed, which were green and sustainable without transition-metal catalysts and stoichiometric oxidants.
An unprecedented metal-free regioselective halogenation of 2H-indazoles is reported, and not only realizes the highly selective synthesis of mono-halogenated products, but also complete poly-halogenations.
The recent advances in the construction of N–N bond from primary and secondary amines via direct oxidation method, is an interest of both academia and industry for preparing the organic frameworks such as azos, hydrazines, indazoles and triazoles.