Recent advances in synthetic strategies of isoxazoles and their role in medicinal chemistry.
Lone pair electrons dominate the binding of isoxazole derivatives to metal oxide surfaces, while aromatic groups show reduced affinity, revealing a fundamental shift from metal to metal oxide surface interactions.
Resistance to conventional therapies in pancreatic and hematologic malignancies highlights the need for novel agents that selectively induce tumor cell death.
The study summarizes the findings from the last eight years of research on heterocyclic core-based epidermal growth factor receptor inhibitors. This provides an invaluable tool for oncology drug discovery.
This review summarizes the latest trends and developments of isoxazole-enabled alkyne amination reactions and their applications in divergent heterocycle synthesis.