Chen-Yu Chiang, Masao Ohashi and Yi Tang
Nat. Prod. Rep., 2023,40, 89-127
From themed collection:
Engineering the biosynthesis of fungal natural products
Abstract
Heterologous expression of biosynthetic gene clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways, bottom-up investigation of biosynthetic enzymes, and engineered biosynthesis of new natural product variants.
Karin Steffen, Manuel Rangel-Grimaldo, Thomas J. C. Sauters, David C. Rinker, Huzefa A. Raja, Tyler N. Graf, Adiyantara Gumilang, Olivia L. Riedling, Gustavo H. Goldman, Nicholas H. Oberlies and Antonis Rokas
Org. Biomol. Chem., 2026, Advance Article
Abstract
Fungi are well known to biosynthesize structurally complex secondary metabolites (SMs) with diverse bioactivities.
Constanze Lasch, Maksym Myronovskyi and Andriy Luzhetskyy
Nat. Prod. Rep., 2026, Advance Article
From themed collection:
Microbial Host and Metabolic Engineering for Natural Product Discovery and Production
Abstract
This review outlines recent strategies for genome mining, synthetic refactoring, and host-based expression of natural product biosynthetic gene clusters, focusing on discovery, dereplication, and scalable production.
Bruno S. Paulo, Michael J. J. Recchia, Sanghoon Lee, Claire H. Fergusson, Sean B. Romanowski, Antonio Hernandez, Nyssa Krull, Dennis Y. Liu, Hannah Cavanagh, Allyson Bos, Christopher A. Gray, Brian T. Murphy, Roger G. Linington and Alessandra S. Eustaquio
Chem. Sci., 2024,15, 16567-16581
Abstract
Megapolipeptins show low structural similarity to known natural products, highlighting the advantage of our Burkholderiales genomics-driven and synthetic biology-enabled pipeline to discover novel natural products.
Chang-Hun Ji, Hyun-Woo Je, Hiyoung Kim and Hahk-Soo Kang
Nat. Prod. Rep., 2024,41, 672-699
Abstract
Promoter engineering has been used to improve production titers of natural products or to activate transcriptionally silent BGCs. This review summarizes 10 years of progress in promoter engineering approaches in natural products research.