Artificial nitroalkane oxidases based on catalytic amounts of flavins enable nitroalkane umpolung resulting in β-nitroalcohols. Two alternative pathways via flavin-5-iminium species are possible.
AtHNL variants displayed improved substrate scope enantioselectivity and catalytic efficiency in the asymmetric Henry reaction in the synthesis of diverse β-nitroalcohols including (R)-tembamide intermediate.
A Cu-bis(sulfonamide)–diamine complex catalytic system was exploited in asymmetric Henry reactions to construct versatile chiral nitroalcohols with high enantioselectivity from carbamate acetaldehydes and nitromethane.
This review explores linear cascade reactions by combining chemo-, photo- and biocatalysts for organic synthesis and strategies to overcome incompatibility issues.
Carbon–carbon (C–C) bond formation can be accomplished by various highly chemo-, regio- and/or stereoselective enzymatic reactions, sometimes through the catalytic promiscuity of enzymes.