Recent advances in HAT-induced C(sp3)–H functionalizations triggered by radical addition to alkynes, including 5-exo-trig, 5-endo-trig, 4-exo-trig and 6-endo-trig cyclization cascades, and intermolecular functionalizations, are summarized.
Localized heating of new alkoxyamine-grafted iron oxide nanoparticles under light irradiation or alternating current magnetic field stimuli enables highly accelerated and spatially controlled radical release.
Photorearrangement of the nitrone group into the oxaziridine one in the nitroxide part of alkoxyamines leads to a decrease in the homolysis activation energy of up to 10 kJ mol−1.
This review presents a concise summary of recent progress in the field of 5-endo-trig radical cyclization, elucidating effective strategies for facilitating this significant yet challenging cyclization process.
New magnetic Fe3O4 nanoparticles covalently grafted with a thermosensitive alkoxyamine molecule are able to provide a localised and direct release of radicals through a cascade action remotely triggered by an ac magnetic field.