Qin Song, Qianer Zhang, Xuejing Fan, Fatmata Kayaat, Ruicheng Lv, Jing Li and Yong Wang
Org. Biomol. Chem., 2024,22, 5374-5384
Abstract
Novel imidazo[1,2-a]pyridine-based covalent inhibitors were synthesized via the scaffold hopping strategy. In vitro bioactivity assessment concluded that I-11 is a potent and selective KRAS G12C inhibitor.
Qiyue Luan, Ines Pulido, Angelique Isagirre, Julian Carretero, Jian Zhou, Takeshi Shimamura and Ian Papautsky
Lab Chip, 2024,24, 2025-2038
Abstract
Agarose microwell platform for modeling lung carcinoma using patient-derived tissues to decipher cancer associated fibroblast-induced drug resistance.
Vineet Prajapati, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Vikas Kumar, Habibullah Khalilullah, Amita Verma and Pradeep Kumar
RSC Med. Chem., 2025,16, 1923-1940
Abstract
Normal and oncogenic RAS signalling pathway along with inhibitors.
Sadaf Dorandish, Komal Bhayekar, Anuradha Singh, Narva Deshwar Kushwaha, Evan Malin, Sara Serafimovski, Jeremy M. Kelm, Navnath S. Gavande and Naga Rajiv Lakkaniga
RSC Med. Chem., 2025,16, 3429-3455
Abstract
KRAS G12 mutations drive aggressive cancers. Once considered undruggable, several strategies evolved in the last decade to target OFF and ON states. Approval of inhibitors and the growing pipeline offer great hope to patients.
Waqas Haider, Sobia Chashman, Wei Pan, Waqas Niaz, Yasothamani Vellingiri, Muhammad Fayaz, Muhammad Rafiq, Muhammad Rizwan, Hailin Cong and Bing Yu
New J. Chem., 2025,49, 13224-13243
From themed collection:
2025 Focus and Perspective articles
Abstract
Penicillium brefeldianum is a filamentous fungus known for its ability to produce a wide range of bioactive secondary metabolites and industrially relevant enzymes.