In this perspective, we summarize recent advances in visible-light-driven defluorinative functionalization of α-trifluoromethyl arylalkenes, highlighting the strategies for gem-difluoroalkene synthesis via photoinduced SET and radical–polar crossover.
In this paper, the diverse transformations of α-trifluoromethyl olefins, mainly including difunctionalization of α-trifluoromethyl olefins, defluorination functionalization to gem-difluoroalkenes, and other types, are described.
The latest achievements in transition-metal-catalyzed enantioselective defluorinative coupling reactions have been comprehensively summarized on the basis of the classification of transition-metal catalysts.
A visible-light-mediated selective difluoroalkylation of α-trifluoromethyl alkenes with difluoroalkylating reagents was developed. This protocol allowed the formation of gem-difluoroalkene difluoroacetates and trifluoromethylated difluoroacetamides.
A practical strategy for the photoinduced defluorinative alkylation of α-trifluoromethyl styrenes with carbonyl derivatives via C–C bond cleavage was disclosed.