In this paper, the diverse transformations of α-trifluoromethyl olefins, mainly including difunctionalization of α-trifluoromethyl olefins, defluorination functionalization to gem-difluoroalkenes, and other types, are described.
The latest achievements in transition-metal-catalyzed enantioselective defluorinative coupling reactions have been comprehensively summarized on the basis of the classification of transition-metal catalysts.
A photocatalytic methodology for the chemodivergent direct cross-coupling of simple alkanes with trifluoromethyl alkenes that enables the selective formation of gem-difluoroalkenes and trifluoromethyl alkanes is presented.
A visible-light-mediated selective difluoroalkylation of α-trifluoromethyl alkenes with difluoroalkylating reagents was developed. This protocol allowed the formation of gem-difluoroalkene difluoroacetates and trifluoromethylated difluoroacetamides.
A practical strategy for the photoinduced defluorinative alkylation of α-trifluoromethyl styrenes with carbonyl derivatives via C–C bond cleavage was disclosed.