Lung-on-chip microdevices to foster pulmonary drug discovery

Yashi Sisodia, Komal Shah, Adil Ali Sayyed, Meenakshi Jain, Syed Ansar Ali, Piyush Gondaliya, Kiran Kalia and Rakesh Kumar Tekade

Biomater. Sci., 2023, 11, 777
DOI: 10.1039/D2BM00951J

Curvature facilitates podocyte culture in a biomimetic platform

Anastasia Korolj, Carol Laschinger, Chris James, Erding Hu, Claire Velikonja, Nathaniel Smith, Irene Gu, Samad Ahadian, Robert Willette, Milica Radisic and Boyang Zhang

Lab Chip, 2018, 18, 3112
DOI: 10.1039/C8LC00495A

Innovative human-specific investigational approaches to autoimmune disease

Anja van de Stolpe and Robert H. Kauffmann

RSC Adv., 2015, 5, 18451
DOI: 10.1039/C4RA15794J

A compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood–retinal barrier

Jose Yeste, Marta García-Ramírez, Xavi Illa, Anton Guimerà, Cristina Hernández, Rafael Simó and Rosa Villa

Lab Chip, 2018, 18, 95
DOI: 10.1039/C7LC00795G

Microscopic artificial cilia – a review

Tanveer ul Islam, Ye Wang, Ishu Aggarwal, Zhiwei Cui, Hossein Eslami Amirabadi, Hemanshul Garg, Roel Kooi, Bhavana B. Venkataramanachar, Tongsheng Wang, Shuaizhong Zhang, Patrick R. Onck and Jaap M. J. den Toonder

Lab Chip, 2022, 22, 1650
DOI: 10.1039/D1LC01168E

Organ-on-a-chip devices advance to market

Boyang Zhang and Milica Radisic

Lab Chip, 2017, 17, 2395
DOI: 10.1039/C6LC01554A

Accelerating drug discovery via organs-on-chips

Chung Yu Chan, Po-Hsun Huang, Feng Guo, Xiaoyun Ding, Vivek Kapur, John D. Mai, Po Ki Yuen and Tony Jun Huang

Lab Chip, 2013, 13, 4697
DOI: 10.1039/c3lc90115g

A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice

Li Wang, Tingting Tao, Wentao Su, Hao Yu, Yue Yu and Jianhua Qin

Lab Chip, 2017, 17, 1749
DOI: 10.1039/C7LC00134G

Macroporous microcarriers for introducing cells into a microfluidic chip

G. Bergström, K. Nilsson, C.-F. Mandenius and N. D. Robinson

Lab Chip, 2014, 14, 3502
DOI: 10.1039/C4LC00693C

Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing

Xingyuan Yang, Kaiyan Li, Xu Zhang, Chang Liu, Bingkun Guo, Weijia Wen and Xinghua Gao

Lab Chip, 2018, 18, 486
DOI: 10.1039/C7LC01224A

Bubble gate for in-plane flow control

Ali Oskooei, Milad Abolhasani and Axel Günther

Lab Chip, 2013, 13, 2519
DOI: 10.1039/c3lc50075f

Bioartificial liversin vitroandin vivo: tailoring biocomponents to the expanding variety of applications

Martien van Wenum, Robert AFM Chamuleau, Thomas M van Gulik, Adriaan Siliakus, Jurgen Seppen and Ruurdtje Hoekstra

Expert Opinion on Biological Therapy, 2014, 14, 1745
DOI: 10.1517/14712598.2014.950651

Microfluidic Fabrication of Biomimetic Helical Hydrogel Microfibers for Blood‐Vessel‐on‐a‐Chip Applications

Luanluan Jia, Fengxuan Han, Huili Yang, Gareth Turnbull, Jiayuan Wang, Jon Clarke, Wenmiao Shu, Mingyu Guo and Bin Li

Adv Healthcare Materials, 2019, 8
DOI: 10.1002/adhm.201900435

Combined Femtosecond Laser Glass Microprocessing for Liver-on-Chip Device Fabrication

Agnė Butkutė, Tomas Jurkšas, Tomas Baravykas, Bettina Leber, Greta Merkininkaitė, Rugilė Žilėnaitė, Deividas Čereška, Aiste Gulla, Mindaugas Kvietkauskas, Kristina Marcinkevičiūtė, Peter Schemmer and Kęstutis Strupas

Materials, 2023, 16, 2174
DOI: 10.3390/ma16062174

Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations

Yi Zhao, Ranjith Kumar Kankala, Shi-Bin Wang and Ai-Zheng Chen

Molecules, 2019, 24, 675
DOI: 10.3390/molecules24040675

Skeletal Muscle Differentiation on a Chip Shows Human Donor Mesoangioblasts’ Efficiency in Restoring Dystrophin in a Duchenne Muscular Dystrophy Model

Elena Serena, Susi Zatti, Alice Zoso, Francesca Lo Verso, F. Saverio Tedesco, Giulio Cossu and Nicola Elvassore

Stem Cells Translational Medicine, 2016, 5, 1676
DOI: 10.5966/sctm.2015-0053

PDMS-based porous membrane for medical applications: design, development, and fabrication

Mohsen Mashhadi Keshtiban, Mahdi Moghimi Zand, Amirali Ebadi and Zahra Azizi

Biomed. Mater., 2023, 18, 045012
DOI: 10.1088/1748-605X/acbddb

Advances in organ-on-a-chip engineering

Boyang Zhang, Anastasia Korolj, Benjamin Fook Lun Lai and Milica Radisic

Nat Rev Mater, 2018, 3, 257
DOI: 10.1038/s41578-018-0034-7

Low-Impedance PEDOT:PSS MEA Integrated in a Stretchable Organ-on-Chip Device

Affan K. Waafi, Nikolas Gaio, William F. Quiros-Solano, Paul Dijkstra, Pasqualina M. Sarro and Ronald Dekker

IEEE Sensors J., 2020, 20, 1150
DOI: 10.1109/JSEN.2019.2946854

Human Organs‐on‐Chips: A Review of the State‐of‐the‐Art, Current Prospects, and Future Challenges

Payam Zarrintaj, Mohammad Reza Saeb, Florian J. Stadler, Mohsen Khodadadi Yazdi, Mojtaba Nasiri Nezhad, Shabnam Mohebbi, Farzad Seidi, Mohammad Reza Ganjali and Masoud Mozafari

Advanced Biology, 2022, 6
DOI: 10.1002/adbi.202000526

Wound-on-a-chip: High-throughput 3D wound healing assay with a novel SU-8 mesh chip

Yachao Wang, Jinchi Zhu, Peng Chen, Yiwei Li, Shuangqian Yan, Jie Wang, Wei Du and Bi-Feng Liu

Sensors and Actuators B: Chemical, 2019, 280, 86
DOI: 10.1016/j.snb.2018.10.050

Organ‐on‐a‐Chip Systems: Microengineering to Biomimic Living Systems

Fuyin Zheng, Fanfan Fu, Yao Cheng, Chunyan Wang, Yuanjin Zhao and Zhongze Gu

Small, 2016, 12, 2253
DOI: 10.1002/smll.201503208

Three‐dimensional in vitro cell culture devices using patient‐derived cells for high‐throughput screening of drug combinations

Seok‐Joon Kwon, Dongwoo Lee, Sneha Gopal, Ashlyn Ku, Hosang Moon and Jonathan S. Dordick

Med Devices & Sens, 2020, 3
DOI: 10.1002/mds3.10067

Enabling precision medicine by unravelling disease pathophysiology: quantifying signal transduction pathway activity across cell and tissue types

Anja van de Stolpe, Laurent Holtzer, Henk van Ooijen, Marcia Alves de Inda and Wim Verhaegh

Sci Rep, 2019, 9
DOI: 10.1038/s41598-018-38179-x

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

Haitao Liu, Yaqing Wang, Kangli Cui, Yaqiong Guo, Xu Zhang and Jianhua Qin

Advanced Materials, 2019, 31
DOI: 10.1002/adma.201902042

The characterization of PVA/PHY hydrogels for 3D printing fabrication of organ phantoms

E.S. Statnik, E.A. Sorokina, I.I. Larin, Kan Yu, A.I. Salimon, Kalyaev V.Yu., D.D. Zherebtsov, Zadorozhnyy M.Yu. and Korsunsky A.M.

Materials Today: Proceedings, 2020, 33, 1874
DOI: 10.1016/j.matpr.2020.05.343

Stem cell-derived intestinal organoids: a novel modality for IBD

Cheng-mei Tian, Mei-feng Yang, Hao-ming Xu, Min-zheng Zhu, Ning-Ning Yue, Yuan Zhang, Rui-yue Shi, Jun Yao, Li-sheng Wang, Yu-jie Liang and De-feng Li

Cell Death Discov., 2023, 9
DOI: 10.1038/s41420-023-01556-1

Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery

Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen and Jospeh C. Wu

Advanced Science, 2026, 13
DOI: 10.1002/advs.202522276

Rapid generation of collagen-based microtissues to study cell–matrix interactions

Marie-Elena Brett, Alexandra L. Crampton and David K. Wood

Technology, 2016, 04, 80
DOI: 10.1142/S2339547816400094

Fabrication of Biomimetic Cell Culture Membranes Using Robust and Reusable Nickel Micropillar Molds

Taiki Otomo, Hyunsoo Noh, Tatsuya Matsubara, Deok-Ho Kim, Masashi Ikeuchi, Kazuhiro Yoshida and Joon-wan Kim

BioChip J, 2025, 19, 91
DOI: 10.1007/s13206-024-00179-7

Organ-On-A-Chip: Development and Clinical Prospects Toward Toxicity Assessment with an Emphasis on Bone Marrow

Jeehye Kim, Hanna Lee, Šeila Selimović, Robert Gauvin and Hojae Bae

Drug Saf, 2015, 38, 409
DOI: 10.1007/s40264-015-0284-x

Reduction of Animal Sacrifice in Biomedical Science & Research through Alternative Design of Animal Experiments

Jagdish Rai and Kuldeep Kaushik

Saudi Pharmaceutical Journal, 2018, 26, 896
DOI: 10.1016/j.jsps.2018.03.006

Development of Organs-on-Chips and Their Impact on Precision Medicine and Advanced System Simulation

Ying Luo, Xiaoxiao Li, Yawei Zhao, Wen Zhong, Malcolm Xing and Guozhong Lyu

Pharmaceutics, 2023, 15, 2094
DOI: 10.3390/pharmaceutics15082094

Dissolvable temporary barrier: a novel paradigm for flexible hydrogel patterning in organ-on-a-chip models

Ding Wang, Qinyu Li, Chenyang Zhou, Zhangjie Li, Kangyi Lu, Yijun Liu, Lian Xuan and Xiaolin Wang

Bio-des. Manuf., 2024, 7, 153
DOI: 10.1007/s42242-023-00267-x

Breast cancer brain metastasis: evaluating the effectiveness of alginate-based organoids in metastasis modeling to replace matrigel

Sepehr Zamani, Fateme Sadat Bitaraf and Mohammad Kamalabadi-Farahani

BMC Res Notes, 2025, 18
DOI: 10.1186/s13104-025-07154-x

Metal and Polymeric Strain Gauges for Si-Based, Monolithically Fabricated Organs-on-Chips

William F. Quirós-Solano, Nikolas Gaio, Cinzia Silvestri, Gregory Pandraud, Ronald Dekker and Pasqualina M. Sarro

Micromachines, 2019, 10, 536
DOI: 10.3390/mi10080536

Circulating Tumor Cells: What Is in It for the Patient? A Vision towards the Future

Anja Van de Stolpe and Jaap Den Toonder

Cancers, 2014, 6, 1195
DOI: 10.3390/cancers6021195

Human immunity in vitro — Solving immunogenicity and more

Christoph Giese and Uwe Marx

Advanced Drug Delivery Reviews, 2014, 69-70, 103
DOI: 10.1016/j.addr.2013.12.011

PEDOT:PSS: A Conductive and Flexible Polymer for Sensor Integration in Organ-on-Chip Platforms

W.F. Quirós-Solano, N. Gaio, C. Silvestri, G. Pandraud and P.M. Sarro

Procedia Engineering, 2016, 168, 1184
DOI: 10.1016/j.proeng.2016.11.401

Advances and Challenges in Recapitulating Human Pulmonary Systems: At the Cusp of Biology and Materials

Piyush Bajaj, Jennifer F. Harris, Jen-Huang Huang, Pulak Nath and Rashi Iyer

ACS Biomater. Sci. Eng., 2016, 2, 473
DOI: 10.1021/acsbiomaterials.5b00480

Cytostretch, an Organ-on-Chip Platform

Nikolas Gaio, Berend Van Meer, William Quirós Solano, Lambert Bergers, Anja Van de Stolpe, Christine Mummery, Pasqualina Sarro and Ronald Dekker

Micromachines, 2016, 7, 120
DOI: 10.3390/mi7070120

Building a microphysiological skin model from induced pluripotent stem cells

Zongyou Guo, Claire A Higgins, Brian M Gillette, Munenari Itoh, Noriko Umegaki, Karl Gledhill, Samuel K Sia and Angela M Christiano

Stem Cell Res Ther, 2013, 4
DOI: 10.1186/scrt363

Measurement of activity of developmental signal transduction pathways to quantify stem cell pluripotency and phenotypically characterize differentiated cells

Laurent Holtzer, Yvonne Wesseling-Rozendaal, Wim Verhaegh and Anja van de Stolpe

Stem Cell Research, 2022, 61, 102748
DOI: 10.1016/j.scr.2022.102748

Biodesign: An Innovative Technology for Sustainable Development Goals in Health and Environment

Adnan Ahmad, Mohammad Haneef, Nabeel Ahmad, Fariya Khan, Samriddhi Jaswani, Tuba Arif and Samiya Shakil

Biomed. Pharmacol. J., 2024, 17, 105
DOI: 10.13005/bpj/2838

Development of a three-dimensional cell culture system based on microfluidics for nuclear magnetic resonance and optical monitoring

Vicent Esteve, Javier Berganzo, Rosa Monge, M. Carmen Martínez-Bisbal, Rosa Villa, Bernardo Celda and Luis Fernandez

Biomicrofluidics, 2014, 8
DOI: 10.1063/1.4902002

Current nano/biotechnological approaches in amyotrophic lateral sclerosis

Inhee Choi, Elizabeth Lee and Luke P. Lee

Biomed. Eng. Lett., 2013, 3, 209
DOI: 10.1007/s13534-013-0114-y

A Novel Modular Bioreactor to In Vitro Study the Hepatic Sinusoid

Xavi Illa, Sergi Vila, Jose Yeste, Carmen Peralta, Jordi Gracia-Sancho, Rosa Villa and Matias A. Avila

PLoS ONE, 2014, 9, e111864
DOI: 10.1371/journal.pone.0111864

Exploiting DNA repair defects for novel cancer therapies

Dik C. van Gent, Roland Kanaar and Doug Kellogg

MBoC, 2016, 27, 2145
DOI: 10.1091/mbc.E15-10-0698

Microfluidics for Cancer Nanomedicine: From Fabrication to Evaluation

Hao Zhang, Yifeng Zhu and Youqing Shen

Small, 2018, 14
DOI: 10.1002/smll.201800360

Fabrication of a pumpless, microfluidic skin chip from different collagen sources

Hyun Jeong Song, Ho Young Lim, Wook Chun, Kyung Chan Choi, Jong Hwan Sung and Gun Yong Sung

Journal of Industrial and Engineering Chemistry, 2017, 56, 375
DOI: 10.1016/j.jiec.2017.07.034

Development of Advanced Cell-Based Therapy by Regulating Cell–Cell Interactions

Kosuke Kusamori

Biological & Pharmaceutical Bulletin, 2021, 44, 1029
DOI: 10.1248/bpb.b21-00276

Organs-on-a-chip: a new tool for drug discovery

Alessandro Polini, Ljupcho Prodanov, Nupura S Bhise, Vijayan Manoharan, Mehmet R Dokmeci and Ali Khademhosseini

Expert Opinion on Drug Discovery, 2014, 9, 335
DOI: 10.1517/17460441.2014.886562

Multiscale tissue engineering for liver reconstruction

Ryo Sudo

Organogenesis, 2014, 10, 216
DOI: 10.4161/org.27968

Advances and challenges in organ-on-chip technology: toward mimicking human physiology and disease in vitro

Dhiraj Kumar, Rahul Nadda and Ramjee Repaka

Med Biol Eng Comput, 2024, 62, 1925
DOI: 10.1007/s11517-024-03062-7

The Role of Silicon Technology in Organ‐On‐Chip: Current Status and Future Perspective

Frøydis Sved Skottvoll, Enrique Escobedo‐Cousin and Michal Marek Mielnik

Adv Materials Technologies, 2025, 10
DOI: 10.1002/admt.202401254

Hybrid business models for ‘Organ-on-a-Chip’ technology: The best of both worlds

Linda H.M. van de Burgwal, Pim van Dorst, Henk Viëtor, Regina Luttge and Eric Claassen

PharmaNutrition, 2018, 6, 55
DOI: 10.1016/j.phanu.2018.02.001

Organs-on-Chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment

Heleen H.T. Middelkamp, Andries D. van der Meer, J. Marjan Hummel, Dimitrios F. Stamatialis, Christine L. Mummery, Robert Passier and Maarten J. IJzerman

Applied In Vitro Toxicology, 2016, 2, 74
DOI: 10.1089/aivt.2015.0029

Microfluidic devices for the detection of disease-specific proteins and other macromolecules, disease modelling and drug development: A review

S. Amir, A. Arathi, S. Reshma and P.V. Mohanan

International Journal of Biological Macromolecules, 2023, 235, 123784
DOI: 10.1016/j.ijbiomac.2023.123784

The Role of Microfluidics for Organ on Chip Simulations

Aziz Aziz, Chunyang Geng, Mengjie Fu, Xiaohui Yu, Kairong Qin and Bo Liu

Bioengineering, 2017, 4, 39
DOI: 10.3390/bioengineering4020039

A Perspective on Studying G-Protein–Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms

Jakobus van Unen, Jeanette Woolard, Ago Rinken, Carsten Hoffmann, Stephen J. Hill, Joachim Goedhart, Michael R. Bruchas, Michel Bouvier and Merel J.W. Adjobo-Hermans

Molecular Pharmacology, 2015, 88, 589
DOI: 10.1124/mol.115.098897

Organs-on-a-Chip: A Future of Rational Drug-Design

Stephen Shay

JBM, 2017, 05, 22
DOI: 10.4236/jbm.2017.59003

Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research

Gill Langley, Christopher P. Austin, Anil K. Balapure, Linda S. Birnbaum, John R. Bucher, Julia Fentem, Suzanne C. Fitzpatrick, John R. Fowle, Robert J. Kavlock, Hiroaki Kitano, Brett A. Lidbury, Alysson R. Muotri, Shuang-Qing Peng, Dmitry Sakharov, Troy Seidle, Thales Trez, Alexander Tonevitsky, Anja van de Stolpe, Maurice Whelan and Catherine Willett

Environ Health Perspect, 2015, 123
DOI: 10.1289/ehp.1510345

Directed Differentiation of Adipose-Derived Stem Cells Using Imprinted Cell-Like Topographies as a Growth Factor-Free Approach

Hamed Nosrati, Mahsa Fallah Tafti, Hossein Aghamollaei, Shahin Bonakdar and Mehrdad Moosazadeh Moghaddam

Stem Cell Rev and Rep, 2024, 20, 1752
DOI: 10.1007/s12015-024-10767-7

Advances in pulmonary therapy and drug development: Lung tissue engineering to lung-on-a-chip

Ali Doryab, Ghassem Amoabediny and Amir Salehi-Najafabadi

Biotechnology Advances, 2016, 34, 588
DOI: 10.1016/j.biotechadv.2016.02.006

Controlling Differentiation of Stem Cells for Developing Personalized Organ‐on‐Chip Platforms

Armin Geraili, Parya Jafari, Mohsen Sheikh Hassani, Behnaz Heidary Araghi, Mohammad Hossein Mohammadi, Amir Mohammad Ghafari, Sara Hasanpour Tamrin, Hassan Pezeshgi Modarres, Ahmad Rezaei Kolahchi, Samad Ahadian and Amir Sanati‐Nezhad

Adv Healthcare Materials, 2018, 7
DOI: 10.1002/adhm.201700426

Application of biomaterials to advance induced pluripotent stem cell research and therapy

Zhixiang Tong, Aniruddh Solanki, Allison Hamilos, Oren Levy, Kendall Wen, Xiaolei Yin and Jeffrey M Karp

The EMBO Journal, 2015, 34, 987
DOI: 10.15252/embj.201490756

Development of 3D skin-equivalent in a pump-less microfluidic chip

Hyun Jeong Song, Ho Young Lim, Wook Chun, Kyung Chan Choi, Tai-yong Lee, Jong Hwan Sung and Gun Yong Sung

Journal of Industrial and Engineering Chemistry, 2018, 60, 355
DOI: 10.1016/j.jiec.2017.11.022

Mussel‐inspired biomaterials: From chemistry to clinic

Ali Taghizadeh, Mohsen Taghizadeh, Mohsen Khodadadi Yazdi, Payam Zarrintaj, Joshua D. Ramsey, Farzad Seidi, Florian J. Stadler, Haeshin Lee, Mohammad Reza Saeb and Masoud Mozafari

Bioengineering & Transla Med, 2022, 7
DOI: 10.1002/btm2.10385

Morphological Transformation between Flat and Tube Structures by Coordinated Motions of Soft Pneumatic Microactuators

Satoshi Konishi and Fumitaka Oya

Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-50670-7

Hydrogel-based microfluidic incubator for microorganism cultivation and analyses

Dietmar Puchberger-Enengl, Sander van den Driesche, Christian Krutzler, Franz Keplinger and Michael J. Vellekoop

Biomicrofluidics, 2015, 9
DOI: 10.1063/1.4913647

Progress and future of in vitro models to study translocation of nanoparticles

Hedwig M. Braakhuis, Samantha K. Kloet, Sanja Kezic, Frieke Kuper, Margriet V. D. Z. Park, Susann Bellmann, Meike van der Zande, Séverine Le Gac, Petra Krystek, Ruud J. B. Peters, Ivonne M. C. M. Rietjens and Hans Bouwmeester

Arch Toxicol, 2015, 89, 1469
DOI: 10.1007/s00204-015-1518-5

Cardiomyocyte culture — an update on the in vitro cardiovascular model and future challenges

Sreejit Parameswaran, Sujeet Kumar, Rama Shanker Verma and Rajendra K. Sharma

Can. J. Physiol. Pharmacol., 2013, 91, 985
DOI: 10.1139/cjpp-2013-0161