Issue 9, 2016

A ratiometric fluorescent sensor for the mitochondrial copper pool

Abstract

Copper plays a key role in the modulation of cellular function, defence, and growth. Here we present InCCu1, a ratiometric fluorescent sensor for mitochondrial copper, which changes from red to blue emission in the presence of Cu(I). Employing this probe in microscopy and flow cytometry, we show that cisplatin-treated cells have an impaired ability to accumulate copper in the mitochondria.

Graphical abstract: A ratiometric fluorescent sensor for the mitochondrial copper pool

Supplementary files

Article information

Article type
Communication
Submitted
31 mar 2016
Accepted
19 aug 2016
First published
23 aug 2016

Metallomics, 2016,8, 915-919

Author version available

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