Phosphination of aryl/alkyl bromides via Mn-mediated reductive C–P coupling

Abstract

Mn-mediated reductive cross-coupling of organic bromides with 2-bromo-1,3,2-diazaphospholene was developed for efficient construction of C–P bonds under mild conditions. Mechanistic studies suggested that bromides are activated by in situ formed bis-diazaphospholene via hybrid radical and polar mechanisms.