A Povarov-Type Reaction to Access Tetrahydroquinolines from N-Benzylhydroxylamines and Alkenes in HFIP
Abstract
Here, we report the synthesis of tetrahydroquinolines between newly developed N-benzylhydroxylamine reagents and alkenes using HFIP as a solvent. This transformation is notably applicable to highly electronically deactivated styrenes and aliphatic alkenes, expanding the range of tetrahydroquinolines attainable.
- This article is part of the themed collections: ChemComm 60th Anniversary Collection and Chemical Communications HOT Articles 2024