Vladyslav Shenderman and Evgeny V. Prusov
Org. Biomol. Chem., 2019,17, 1362-1364
DOI:
10.1039/C8OB02890G,
Communication
Several monocyclic derivatives of 14,14′-difluororipostatin A were prepared using a catalytic Mukaiyama aldol reaction, a ring-closing metathesis reaction and a late stage click reaction as key steps. The biological activity of the produced compounds was assessed in vivo using a panel of pathogenic microorganisms. Moderate antibiotic activity was observed for 11-OMe-ripostatin A and 11-OMe-14,14′-difluororipostatin A.
