Issue 35, 2015
From the journal:

Journal of Materials Chemistry B

Virus-inspired mimics: self-assembly of dendritic lipopeptides into arginine-rich nanovectors for improving gene delivery†

Xianghui Xu,a   Qian Jiang,a   Xiao Zhang,a   Yu Nie,*a   Zhijun Zhang,a   Yunkun Li,a   Gang Chenga  and  Zhongwei Gu*a  

* Corresponding authors

a National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, China
E-mail: zwgu@scu.edu.cn, nie_yu@scu.edu.cn
Fax: +86 28-85410653
Tel: +86 28-85414308

Abstract

With inspirations from natural viruses, arginine-containing dendritic lipopeptides were designed for bioinspired fabrication. Self-assembling the defined amphiphilic lipopeptides generated virus-inspired nanovectors with an arginine-rich corona. These nanovectors provided some remarkable benefits for gene delivery, including well-defined nanostructure, high transfection efficiency, serum resistance and low cytotoxicity.

Graphical abstract: Virus-inspired mimics: self-assembly of dendritic lipopeptides into arginine-rich nanovectors for improving gene delivery

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Article information

DOI
https://doi.org/10.1039/C5TB01070E
Article type
Communication
Submitted
03 jun 2015
Accepted
27 jul 2015
First published
28 jul 2015

J. Mater. Chem. B, 2015,3, 7006-7010

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Virus-inspired mimics: self-assembly of dendritic lipopeptides into arginine-rich nanovectors for improving gene delivery

X. Xu, Q. Jiang, X. Zhang, Y. Nie, Z. Zhang, Y. Li, G. Cheng and Z. Gu, J. Mater. Chem. B, 2015, 3, 7006 DOI: 10.1039/C5TB01070E

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