Themed collection Organic Chemistry Frontiers Emerging Investigator Series 2022–2023
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Contributors to the Organic Chemistry Frontiers Emerging Investigator Series 2022–2023
This profile article showcases researchers who have contributed an article to the Organic Chemistry Frontiers Emerging Investigator Series.
Org. Chem. Front., 2024,11, 2149-2154
https://doi.org/10.1039/D4QO90025A
Recent advances in the chemistry of α-oxylboronate reagents
The synthesis and transformation of α-oxylboronates including their C–B bond and C–O bond functionalizations are reviewed.
Org. Chem. Front., 2023,10, 3684-3700
https://doi.org/10.1039/D3QO00521F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
Chiral organophosphates as ligands in asymmetric metal catalysis
Chiral phosphates have successfully been used as ligands in asymmetric metal-catalysis. This Minireview discusses the most recent examples, including main-group catalysis, transition-metal catalysis and catalysis by rare-earth metals.
Org. Chem. Front., 2023,10, 3080-3109
https://doi.org/10.1039/D3QO00206C
N-Amino pyridinium salts in organic synthesis
This review summarizes the synthesis and reactivity of N-aminopyridinium salts, discusses applications in organic synthesis, and highlights the potential for these reagents to enable novel synthetic disconnections and innovations.
Org. Chem. Front., 2023,10, 2563-2580
https://doi.org/10.1039/D3QO00190C
Exploring visible light for carbon–nitrogen and carbon–oxygen bond formation via nickel catalysis
In this review, we highlight the recent synthetic methodology development for the formation of C–N and C–O bonds via visible-light-driven nickel catalysis, with in-depth discussions with reaction designs and mechanistic scenarios.
Org. Chem. Front., 2023,10, 548-569
https://doi.org/10.1039/D2QO01700H
Advances in circularly polarized electroluminescence based on chiral TADF-active materials
This review summarizes the development status of chiral TADF-active materials with CPEL, covering chiral perturbed TADF molecules, intrinsically chiral TADF molecules, and TADFsensitized fluorescent enantiomers.
Org. Chem. Front., 2022,9, 6441-6452
https://doi.org/10.1039/D2QO01383E
Conjugated figure-of-eight macrocycles derived from the anthracene photodimer: synthetic execution through intramolecular cyclization and topological manipulation through ring expansion
Employing the anthracene photodimer core, conjugated figure-of-eight macrocycles are facilely prepared via intramolecular cyclizations followed by ring expansion.
Org. Chem. Front., 2023,10, 5395-5401
https://doi.org/10.1039/D3QO01351K
Electrochemical multicomponent reaction toward vicinal sulfenyltetrazolation of unactivated alkenes
An electrochemical multicomponent reaction (e-MCR) enables the green and sustainable preparation of diverse vicinal sulfenyltetrazolation using the readily available unactivated olefins, thiols, azidotrimethylsilane, and acetonitrile.
Org. Chem. Front., 2023,10, 5064-5069
https://doi.org/10.1039/D3QO01241G
Re-examining the stereochemistry of polycyclic suffruticosine via TDDFT calculations, ECD spectroscopy, and chemical synthesis
The stereochemistry of suffruticosine has been revised by using experimental and computational methods.
Org. Chem. Front., 2023,10, 5123-5129
https://doi.org/10.1039/D3QO01098H
Stereodivergent asymmetric synthesis of P-atropisomeric Si-stereogenic monohydrosilanes
We herein report an efficient one-pot strategy for the stereodivergent asymmetric synthesis of various P-atropisomeric Si-stereogenic monohydrosilanes with excellent stereoselectivity from dichlorosilanes.
Org. Chem. Front., 2023,10, 4862-4870
https://doi.org/10.1039/D3QO01084H
Oxidative Mizoroki–Heck reaction of unprotected cinnamylamines at ambient temperature under air
Cinnamylamines make-up many important drugs that target G protein-coupled receptors.
Org. Chem. Front., 2023,10, 3982-3988
https://doi.org/10.1039/D3QO00778B
Efficient multigram procedure for the synthesis of large hydrazone-linked molecular cages
An efficient pathway to synthesize covalent hydrazone-linked molecular tetrahedra is reported. Our new synthesis enabled us to create a family of hydrolytically stable organic molecular cages with large openings required to bind complex guests.
Org. Chem. Front., 2023,10, 3965-3974
https://doi.org/10.1039/D3QO00480E
Copper-catalysed controllable hydrodefluorination of trifluoromethylated alkenes
An effective method for the construction of difluoromethylated alkenes through Cu-catalysed controllable hydrodefluorination of trifluoromethylated alkenes is described.
Org. Chem. Front., 2023,10, 3811-3818
https://doi.org/10.1039/D3QO00691C
Carboxyl group assisted isodesmic meta-C–H iodination of phenethylamines, benzylamines, and 2-aryl anilines
Remote isodesmic meta-C–H iodination of phenethylamines, benzylamines, and 2-aryl anilines was enabled by an alkyl carboxyl group.
Org. Chem. Front., 2023,10, 3760-3765
https://doi.org/10.1039/D3QO00479A
Pyrene bridged double[7]helicene embedded with a heptagonal ring
The article explores the intricate relationship between chiroptical properties and molecular symmetry of pyrene-conjugated single and double [7]helicene.
Org. Chem. Front., 2023,10, 3714-3725
https://doi.org/10.1039/D3QO00386H
Photoinduced carbene transfer for copper-catalyzed asymmetric [4 + 1] cycloadditions: an entry to chiral indolines bearing quaternary stereocenters
A copper-catalyzed asymmetric [4 + 1] cycloaddition of ethynylbenzoxazinones with sulfur ylides formed in situ by photoinduced carbene transfer is reported to afford chiral indolines with good efficiency, enantio- and diastereoselectivities.
Org. Chem. Front., 2023,10, 3498-3503
https://doi.org/10.1039/D3QO00551H
A practical synthesis of 3,4-diamino-6-azido-1H-pyrazolo[4,3-c]pyridin-5-ium energetic ionic compounds
We report herein a practical synthesis of 3,4-diamino-6-azido-1H-pyrazolo[4,3-c]pyridin-5-ium energetic ionic compounds which show good detonation performances and low sensitivities.
Org. Chem. Front., 2023,10, 2642-2647
https://doi.org/10.1039/D3QO00343D
Redox-active alkyl xanthate esters enable practical C–S cross-coupling by nickel catalysis
A new nickel catalysis strategy that harnesses readily accessible alkyl xanthate esters, while previously well-studied as alkyl radical precursors, herein as ideal sulfenylating agents via an unprecedented C–S bond activation pattern.
Org. Chem. Front., 2023,10, 2505-2516
https://doi.org/10.1039/D3QO00136A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.148/content/NewImages/open-access-icon-orange.png)
One-step synthesis of polycyclic thianthrenes from unfunctionalized aromatics by thia-APEX reactions
In this paper, thia-APEX reactions affording π-extended thianthrene derivatives from unfunctionalized aromatics are described.
Org. Chem. Front., 2023,10, 1880-1889
https://doi.org/10.1039/D2QO02058K
Zinc-catalyzed desymmetric hydrosilylation of monosubstituted malonic esters
A dinuclear zinc catalyst with a pipecolinol-derived tetradentate ligand enables the diverse synthesis of tertiary stereocenters via desymmetrization.
Org. Chem. Front., 2023,10, 1675-1679
https://doi.org/10.1039/D2QO02055F
Nickel-catalyzed desulfonylative olefination of β-hydroxysulfones
A Ni-catalyzed C–O bond activation is used to access alkenes directly from β-hydroxysulfones.
Org. Chem. Front., 2023,10, 1399-1404
https://doi.org/10.1039/D2QO01999J
Bis(pentafluorophenyl)borane-catalyzed E-selective isomerization of terminal alkenes to internal alkenes
The bis(pentafluorophenyl)borane-catalyzed E-selective isomerization of terminal alkenes to internal alkenes via a hydroboration/retro-hydroboration sequence is reported.
Org. Chem. Front., 2023,10, 1128-1133
https://doi.org/10.1039/D2QO01998A
Visible light-mediated NHC and photoredox co-catalyzed 1,2-sulfonylacylation of allenes via acyl and allyl radical cross-coupling
Visible light-mediated NHC and photoredox co-catalyzed radical 1,2-sulfonylacylation of allenes via cross-coupling between an allyl radical and an NHC-stabilized acyl radical.
Org. Chem. Front., 2023,10, 1047-1055
https://doi.org/10.1039/D2QO01993K
Synthesis of 2,4-diarylated pyrimidines enabled by Ni-catalyzed C–sulfone bond activation
The readily available pyrimidinyl sulfones, in which the C–S bond is cleaved selectively, could serve as electrophiles in the Ni-catalyzed cross-coupling reactions to prepare 2,4-diarylated pyrimidines under mild conditions with a broad scope.
Org. Chem. Front., 2023,10, 645-650
https://doi.org/10.1039/D2QO01935C
4,5-Disubstituted pyrenes from phenangermoles
The synthesis of discriminated 4,5-disubstitued pyrene from phenangermoles is accomplished via a Pd-catalyzed annulative π-extension reaction.
Org. Chem. Front., 2023,10, 640-644
https://doi.org/10.1039/D2QO01712A
Cr-catalyzed chiral allenone synthesis via sequential radical–polar crossover and Oppenauer oxidation
We describe the Cr-catalyzed enantioconvergent synthesis of chiral 2,3-allenones from aldehydes and propargyl bromides, which features an unprecedented cascade of Cr-catalyzed asymmetric reductive radical–polar crossover and Oppenauer oxidation.
Org. Chem. Front., 2023,10, 310-316
https://doi.org/10.1039/D2QO01676A
About this collection
Organic Chemistry Frontiers is pleased to publish this Emerging Investigator Series to highlight early-career scientists and their excellent research at the forefront of organic chemistry.
Scientists featured in the collection are recognized for the high novelty of their research, their outstanding contributions made during independent career stages, as well as the potential to influence chemistry in future.
More details about the Emerging Investigator Series can be found below, including details on how to apply for considerations. For the latest work in the collection, explore the Organic Chemistry Frontiers Emerging Investigator Series 2024–2025.
Check out the call for papers by Organic Chemistry Frontiers, Materials Chemistry Frontiers and Inorganic Chemistry Frontiers.
Read below the author profiles to know more about the emerging investigators.