Issue 44, 2023

Recent advances in small-molecule fluorescent probes with the function of targeting cancer receptors

Abstract

Cancer is “the sword of Damocles” that threatens human life and health. Therefore, the diagnosis and treatment of cancer have been receiving much attention. Many overexpressed receptors on the surface of cancer cells provide us with an effective way to specifically identify the cancer cells, and receptor targeting strategies are becoming one of the hot ideas to enhance the ability of fluorescent probes to target tumors. Fluorescent probes connected to ligands are targeted at cancer cell surfaces through receptor-mediated endocytosis. Receptor-targeting probes can image and track cancer cells, determine tumor boundaries, monitor deep lesions, and play a role in clinical medicine, such as fluorescent imaging-guided surgery. In this review, based on the perspective of small molecule fluorescent probes, we reviewed the design ideas, photophysical properties, and applications of receptor-targeting probes for detecting biomarkers in imaging and tracing cancer cells and prospected the future developmental direction of such probes. We hope that this review will provide more ideas for the design and development of active targeting probes for receptors and lead to more applications in the medical field.

Graphical abstract: Recent advances in small-molecule fluorescent probes with the function of targeting cancer receptors

Article information

Article type
Critical Review
Submitted
09 ဩ 2023
Accepted
26 စက် 2023
First published
01 နို 2023

Anal. Methods, 2023,15, 5947-5977

Recent advances in small-molecule fluorescent probes with the function of targeting cancer receptors

X. Li, C. Liu, H. Zhu, K. Wang, X. Ren, L. Ma, X. Zhang, M. Liu and B. Zhu, Anal. Methods, 2023, 15, 5947 DOI: 10.1039/D3AY01387A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements