Issue 7, 2019

A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles

Abstract

We report herein a L-glutamate (L-Glu)-responsive delivery system. It consists of Janus Au–mesoporous silica (MS) nanoparticles functionalized with L-glutamate oxidase on the Au face and with self-immolative arylboronate derivatives as caps on the MS face. The MS face is additionally loaded with a cargo. The delivery paradigm is based on the recognition of L-Glu by the enzyme and the subsequent formation of H2O2, which induces the cleavage of the self-immolative gate and the uncapping of the pores. Given the importance of L-Glu as a key neurotransmitter, we hope that these findings will help in designing new therapeutic strategies for nervous system diseases.

Graphical abstract: A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles

Supplementary files

Article information

Article type
Research Article
Submitted
21 ဇန် 2019
Accepted
11 မတ် 2019
First published
12 မတ် 2019

Org. Chem. Front., 2019,6, 1058-1063

A L-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles

T. M. Godoy-Reyes, A. Llopis-Lorente, A. García-Fernández, P. Gaviña, A. M. Costero, R. Villalonga, F. Sancenón and R. Martínez-Máñez, Org. Chem. Front., 2019, 6, 1058 DOI: 10.1039/C9QO00093C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements