Facile synthesis of carbo- and heterocycles via Fe(iii)-catalyzed alkene hydrofunctionalization

Abstract

A facile synthesis of carbo- and heterocycles via Fe(III)-catalyzed alkene hydrofunctionalization has been developed. Various alkenes bearing a leaving group could convert to alkyl radicals through hydrogen atom transfer (HAT), and then serve as cyclization dipoles for accessing carbo- and heterocycles. The synthetic utility was further demonstrated by the synthesis of tetracyclic carbocycles from isopregol.