Issue 30, 2012

Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4)

Abstract

The development of novel peptide and peptidomimetic ligands for the CXC chemokine receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system diseases has grown over the last decade. In this perspective article, the design of CXCR4 agonists and antagonists from endogenous stromal cell-derived factor-1 (SDF-1)/CXCL12 and horseshoe crab-derived antimicrobial peptides and their therapeutic and diagnostic applications are described.

Graphical abstract: Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4)

Article information

Article type
Perspective
Submitted
14 ဇန် 2012
Accepted
16 မတ် 2012
First published
19 မတ် 2012

Org. Biomol. Chem., 2012,10, 5720-5731

Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4)

S. Oishi and N. Fujii, Org. Biomol. Chem., 2012, 10, 5720 DOI: 10.1039/C2OB25107H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements