Red-light excitation of a Ru(II)–Pt(II) tetranuclear complex for combined photoactivated chemotherapy and photodynamic therapy

Pia Siekierski; Eleni Michaltsis; Julia Schleisiek; Nicolás Montesdeoca; Johannes Karges

doi:10.1039/D5CC05177K

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Red-light excitation of a Ru(ii)–Pt(ii) tetranuclear complex for combined photoactivated chemotherapy and photodynamic therapy

Pia Siekierski,^a Eleni Michaltsis,^a Julia Schleisiek,^a Nicolás Montesdeoca^a and Johannes Karges

*^a

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* Corresponding authors

^a Faculty of Chemistry and Biochemistry, Ruhr-University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany
E-mail: johannes.karges@ruhr-uni-bochum.de
Web: https://www.kargesgroup.ruhr-uni-bochum.de
Tel: +49 2343224187

Abstract

We report the synthesis and biological evaluation of a tetranuclear Ru(II)–Pt(II) complex activated by red light (630 nm). Upon irradiation, the Ru(II) center photo-catalytically generates singlet oxygen while simultaneously releasing Pt(II) moieties, thereby inducing a multimodal therapeutic effect in cancer cells by photodynamic therapy and photoactivated chemotherapy.

This article is part of the themed collection: Photodynamic Therapy (PDT)

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Article information

DOI: https://doi.org/10.1039/D5CC05177K
Article type: Communication
Submitted: 08 Sep 2025
Accepted: 07 Oct 2025
First published: 07 Oct 2025
This article is Open Access

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Chem. Commun., 2025, Advance Article

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Red-light excitation of a Ru(II)–Pt(II) tetranuclear complex for combined photoactivated chemotherapy and photodynamic therapy

P. Siekierski, E. Michaltsis, J. Schleisiek, N. Montesdeoca and J. Karges, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC05177K

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Chemical Communications

Red-light excitation of a Ru(ii)–Pt(ii) tetranuclear complex for combined photoactivated chemotherapy and photodynamic therapy

Abstract

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Red-light excitation of a Ru(II)–Pt(II) tetranuclear complex for combined photoactivated chemotherapy and photodynamic therapy

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