Issue 3, 2024

Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches

Abstract

Precision drug delivery and multimodal synergistic therapy are crucial in treating diverse ailments, such as cancer, tissue damage, and degenerative diseases. Electrodes that emit electric pulses have proven effective in enhancing molecule release and permeability in drug delivery systems. Moreover, the physiological electrical microenvironment plays a vital role in regulating biological functions and triggering action potentials in neural and muscular tissues. Due to their unique noncentrosymmetric structures, many 2D materials exhibit outstanding piezoelectric performance, generating positive and negative charges under mechanical forces. This ability facilitates precise drug targeting and ensures high stimulus responsiveness, thereby controlling cellular destinies. Additionally, the abundant active sites within piezoelectric 2D materials facilitate efficient catalysis through piezochemical coupling, offering multimodal synergistic therapeutic strategies. However, the full potential of piezoelectric 2D nanomaterials in drug delivery system design remains underexplored due to research gaps. In this context, the current applications of piezoelectric 2D materials in disease management are summarized in this review, and the development of drug delivery systems influenced by these materials is forecast.

Graphical abstract: Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches

Article information

Article type
Review Article
Submitted
20 ဒီ 2023
Accepted
02 ဇန် 2024
First published
08 ဇန် 2024

Nanoscale Horiz., 2024,9, 365-383

Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches

A. Li, J. Yang, Y. He, J. Wen and X. Jiang, Nanoscale Horiz., 2024, 9, 365 DOI: 10.1039/D3NH00578J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements