Issue 31, 2023

Utility of CRISPR/Cas mediated electrochemical biosensors

Abstract

Electrochemical biosensors represent a class of sensors that employ biological materials as sensitive elements, electrodes as conversion elements, and potential or current as detection signals. The integration of CRISPR/Cas systems into electrochemical biosensors holds immense potential, offering enhanced versatility, heightened sensitivity and specificity, reduced recovery time, and the ability to capture and identify analytes at low concentrations. In this review, we provided a succinct summary of the fundamental principles underlying electrochemical biosensors and CRISPR/Cas systems, and new progress of electrochemical biosensors based on CRISPR/Cas systems in virus, bacteria, and cancer detections. Besides, we discussed its pros and cons, present gaps, potential problem-solvers, and future prospects. To sum up, CRISPR/Cas mediated electrochemical biosensors will surely benefit us a lot in the detection of cells and microorganisms, and of course in other promising fields.

Graphical abstract: Utility of CRISPR/Cas mediated electrochemical biosensors

Article information

Article type
Tutorial Review
Submitted
03 ဇွန် 2023
Accepted
19 ဇူ 2023
First published
19 ဇူ 2023

Anal. Methods, 2023,15, 3785-3801

Utility of CRISPR/Cas mediated electrochemical biosensors

J. Ma, X. Li, C. Lou, X. Lin, Z. Zhang, D. Chen and S. Yang, Anal. Methods, 2023, 15, 3785 DOI: 10.1039/D3AY00903C

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