Issue 12, 2021

Electrohalogenation of organic compounds

Abstract

Herein, we present an overview of recent advances in the electrochemical halogenation of organic compounds. Halogen-containing compounds are essential building blocks for post-functionalization in academic research and in different industrial sectors, notably pharmaceutical companies. One of the main advantages of using electrosynthesis is its environmentally-friendly characteristics. Electrosynthesis is recognized as a methodology that can fulfill different criteria of the green chemistry concept and constitutes a promising tool in the development of new procedures in organic synthesis. In this review we target sp, sp2 and sp3 carbon fluorination, chlorination, bromination and iodination reactions using electrolysis as a redox medium. Mechanistic insights and substrate reactivity are also discussed.

Graphical abstract: Electrohalogenation of organic compounds

Article information

Article type
Review Article
Submitted
09 ဒီ 2020
Accepted
25 ဖေ 2021
First published
26 ဖေ 2021

Org. Biomol. Chem., 2021,19, 2578-2602

Electrohalogenation of organic compounds

M. R. Scheide, C. R. Nicoleti, G. M. Martins and A. L. Braga, Org. Biomol. Chem., 2021, 19, 2578 DOI: 10.1039/D0OB02459G

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