Issue 16, 2021

A fluorescence color card for point-of-care testing (POCT) and its application in simultaneous detection

Abstract

Diabetes mellitus has received much attention because its complications include liver, kidney, eye, heart and cerebrovascular diseases. Thus, it would be highly significant to develop a rapid and efficient method for glucose detection in biological samples. In this work, a point-of-care testing (POCT) method of glucose detection was proposed using a standard colorimetric card for semi-quantitative determination patterns. In the prepared fluorescence color card for glucose, a good linear relationship was acquired by plotting the ratio of the grayscale value (I/I0) versus the logarithm of glucose concentration within 100.0 to 1000.0 μmol L−1, and the LOD of glucose detection was 1.1 μmol L−1. A large number of actual samples (30 serum and 7 urine) were analyzed and the results demonstrated that this method had good potential to be applied in the primary screening of diabetic patients. In addition, this method is universal and can be applied in the simultaneous detection of multiple small molecules. It provides a new strategy for the primary screening of multiple diseases simultaneously, which presents excellent application potential.

Graphical abstract: A fluorescence color card for point-of-care testing (POCT) and its application in simultaneous detection

Supplementary files

Article information

Article type
Paper
Submitted
12 ဇွန် 2021
Accepted
08 ဇူ 2021
First published
12 ဇူ 2021

Analyst, 2021,146, 5074-5080

A fluorescence color card for point-of-care testing (POCT) and its application in simultaneous detection

F. Lu, S. Yang, Y. Ning, F. Wang, X. Ji and Z. He, Analyst, 2021, 146, 5074 DOI: 10.1039/D1AN01035B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements