Issue 40, 2020

Spatiotemporal regulation of dynamic cell microenvironment signals based on an azobenzene photoswitch

Abstract

Dynamic biochemical and biophysical signals of cellular matrix define and regulate tissue-specific cell functions and fate. To recapitulate this complex environment in vitro, biomaterials based on structural- or degradation-tunable polymers have emerged as powerful platforms for regulating the “on-demand” cell-material dynamic interplay. As one of the most prevalent photoswitch molecules, the photoisomerization of azobenzene demonstrates a unique advantage in the construction of dynamic substrates. Moreover, the development of azobenzene-containing biomaterials is particularly helpful in elucidating cells that adapt to a dynamic microenvironment or integrate spatiotemporal variations of signals. Herein, this minireview, places emphasis on the research progress of azobenzene photoswitches in the dynamic regulation of matrix signals. Some techniques and material design methods have been discussed to provide some theoretical guidance for the rational and efficient design of azopolymer-based material platforms. In addition, considering that the UV-light response of traditional azobenzene photoswitches is not conducive to biological applications, we have summarized the recent approaches to red-shifting the light wavelength for azobenzene activation.

Graphical abstract: Spatiotemporal regulation of dynamic cell microenvironment signals based on an azobenzene photoswitch

Article information

Article type
Review Article
Submitted
14 ဇူ 2020
Accepted
29 ဩ 2020
First published
01 စက် 2020

J. Mater. Chem. B, 2020,8, 9212-9226

Spatiotemporal regulation of dynamic cell microenvironment signals based on an azobenzene photoswitch

K. Wu, J. Sun, Y. Ma, D. Wei, O. Lee, H. Luo and H. Fan, J. Mater. Chem. B, 2020, 8, 9212 DOI: 10.1039/D0TB01737J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements