Issue 17, 2019

Lysosome-targeted carbon dots for ratiometric imaging of formaldehyde in living cells

Abstract

Formaldehyde (FA) is involved in many biological processes and is closely connected with many diseases including Alzheimer's disease and cancer. Therefore, methods for sensitive and selective detection of FA in living cells are highly demanded. As a new class of carbon nanomaterials, carbon dots (CDs) have attracted great attention owing to their robust photostability, good biocompatibility and environmental friendliness. In this manuscript, the first lysosome-targeted CDs for ratiometric fluorescence detection of FA were efficiently prepared from dexamethasone and 1,2,4,5-tetraaminobenzene through the microwave-assisted hydrothermal method. These CDs show highly selective and sensitive sensing ability towards FA with fast response and great changes of ratio values. The CDs exhibit robust photostability and good biocompatibility and were successfully employed in ratiometric fluorescence bioimaging of FA fluctuations in lysosomes of living cells, which demonstrates their great practicability in FA-related bioanalysis and biological studies.

Graphical abstract: Lysosome-targeted carbon dots for ratiometric imaging of formaldehyde in living cells

Supplementary files

Article information

Article type
Paper
Submitted
24 ဖေ 2019
Accepted
03 ဧပြီ 2019
First published
04 ဧပြီ 2019

Nanoscale, 2019,11, 8458-8463

Lysosome-targeted carbon dots for ratiometric imaging of formaldehyde in living cells

H. Liu, Y. Sun, Z. Li, J. Yang, A. A. Aryee, L. Qu, D. Du and Y. Lin, Nanoscale, 2019, 11, 8458 DOI: 10.1039/C9NR01678C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements