Issue 44, 2019

2,4-Substituted bispidines as rigid hosts for versatile applications: from κ-opioid receptor to metal coordination

Abstract

Bispidones (3,7-diazabicyclo[3.3.1]nonan-9-one) are bicyclic analogues of the natural antiarrhythmic agent, spartein. They can straightforwardly be obtained from two successive Mannich reactions. Reduction of the ketone gives the corresponding bispidol. Substituted bispidones and bispidols offer a large playground by varying the substituents, the configuration of the carbon atoms in position 2 and 4 as well as the conformation of the bicycle. While chair–boat conformers display a strong affinity for κ-opioid receptors, chair–chair bispidines provide adaptable coordination spheres for transition metal and rare-earth ions. Because of their very rich coordination chemistry, substituted bispidines have emerged in various applications of coordination chemistry, such as catalysis, magnetism and medical imaging.

Graphical abstract: 2,4-Substituted bispidines as rigid hosts for versatile applications: from κ-opioid receptor to metal coordination

Article information

Article type
Perspective
Submitted
27 ဩ 2019
Accepted
04 အောက် 2019
First published
04 အောက် 2019

Dalton Trans., 2019,48, 16476-16492

2,4-Substituted bispidines as rigid hosts for versatile applications: from κ-opioid receptor to metal coordination

A. M. Nonat, A. Roux, M. Sy and L. J. Charbonnière, Dalton Trans., 2019, 48, 16476 DOI: 10.1039/C9DT03480C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements