Issue 23, 2018

Ni-Catalyzed 1,2-iminoacylation of alkenes via a reductive strategy

Abstract

In this protocol, we developed a reductive strategy for 1,2-iminoacylation of alkenes. Under the catalysis of the Ni-biquinoline system, various oxime esters incorporating a pendant terminal olefinic unit were successfully reacted with acid chlorides or anhydrides as electrophilic acylating reagents in the presence of Zn as a reductant, furnishing a series of pyrrolines in moderate to excellent yields. This reaction is distinguished by safe and mild reaction conditions that avoid the use of CO gas as a carbonyl source, pregenerated organometallics and strong bases as reaction additives.

Graphical abstract: Ni-Catalyzed 1,2-iminoacylation of alkenes via a reductive strategy

Supplementary files

Article information

Article type
Research Article
Submitted
27 စက် 2018
Accepted
23 အောက် 2018
First published
25 အောက် 2018

Org. Chem. Front., 2018,5, 3476-3482

Ni-Catalyzed 1,2-iminoacylation of alkenes via a reductive strategy

L. Wang and C. Wang, Org. Chem. Front., 2018, 5, 3476 DOI: 10.1039/C8QO01044G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements