Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

Feng-Yuan Wang; Qi Zhang; Zaiyong Zhang; Xiaoyi Gong; Jian-Rong Wang; Xuefeng Mei

doi:10.1039/C8CE00689J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals†

Feng-Yuan Wang,^ab Qi Zhang,

^a Zaiyong Zhang,^a Xiaoyi Gong,^a Jian-Rong Wang

^a and Xuefeng Mei

*^a

Author affiliations

* Corresponding authors

^a Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: xuefengmei@simm.ac.cn
Fax: +86 2150807088
Tel: +86 2150800934

^b University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China

Abstract

Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral agent, with nicotinamide, caffeine, and acetylsalicylic acid were successfully designed and synthesized. Both the apparent solubility and intrinsic dissolution rate of apremilast in a pH 2.0 buffer have been improved via the formation of cocrystals.

This article is part of the themed collection: CrystEngComm New Talent

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/C8CE00689J
Article type: Communication
Submitted: 28 ဧပြီ 2018
Accepted: 09 ဩ 2018
First published: 09 ဩ 2018

Download Citation

CrystEngComm, 2018,20, 5945-5948

Permissions

Request permissions

Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

F. Wang, Q. Zhang, Z. Zhang, X. Gong, J. Wang and X. Mei, CrystEngComm, 2018, 20, 5945 DOI: 10.1039/C8CE00689J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

CrystEngComm

Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

Social activity

Search articles by author

Spotlight

Advertisements