Issue 39, 2018

Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

Abstract

Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral agent, with nicotinamide, caffeine, and acetylsalicylic acid were successfully designed and synthesized. Both the apparent solubility and intrinsic dissolution rate of apremilast in a pH 2.0 buffer have been improved via the formation of cocrystals.

Graphical abstract: Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

Supplementary files

Article information

Article type
Communication
Submitted
28 ဧပြီ 2018
Accepted
09 ဩ 2018
First published
09 ဩ 2018

CrystEngComm, 2018,20, 5945-5948

Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

F. Wang, Q. Zhang, Z. Zhang, X. Gong, J. Wang and X. Mei, CrystEngComm, 2018, 20, 5945 DOI: 10.1039/C8CE00689J

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