Issue 76, 2017

Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

Abstract

The well-characterized interaction between the MS2 coat protein and its cognate RNA hairpin was used to evaluate changes in affinity as a result of phosphorodithioate (PS2) replacing phosphate by biolayer interferometry (BLI). A structure-based analysis of the data provides insights into the origins of the enhanced affinity of RNA–protein interactions triggered by the PS2 moiety.

Graphical abstract: Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

Supplementary files

Article information

Article type
Communication
Submitted
23 ဇူ 2017
Accepted
28 ဩ 2017
First published
29 ဩ 2017

Chem. Commun., 2017,53, 10508-10511

Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

X. Yang, N. Dinuka Abeydeera, F. Liu and M. Egli, Chem. Commun., 2017, 53, 10508 DOI: 10.1039/C7CC05722A

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