Issue 24, 2013
From the journal:

Chemical Communications

Light uncages a copper complex to induce nonapoptotic cell death†

Anupa A. Kumbhar,ab   Andrew T. Franks,a   Raymond J. Butcherc  and  Katherine J. Franz*a  

* Corresponding authors

a Duke University, Dept. of Chemistry, 124 Science Dr, Durham, NC, USA
E-mail: katherine.franz@duke.edu
Fax: +1 919 660 1605
Tel: +1 919 660 1541

b Dept. of Chemistry, University of Pune, Pune-411007, India
E-mail: aak@chem.unipune.ac.in
Fax: +91 020 25691728
Tel: +91 020 25601395, Ext. 516

c Dept. of Chemistry, Howard University, Washington, DC, USA
E-mail: rbutcher@fac.howard.edu
Fax: +1 205 806 5442
Tel: +1 202 806 6886

Abstract

Cu3G is a Cu(II) complex of a photoactive tetradentate ligand that is cleaved upon UV irradiation to release Cu. Here we show that the cytotoxicity of Cu3G increases in response to brief UV stimulation to result in extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death.

Graphical abstract: Light uncages a copper complex to induce nonapoptotic cell death

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC38927H
Article type
Communication
Submitted
13 ဒီ 2012
Accepted
04 ဖေ 2013
First published
15 ဖေ 2013

Chem. Commun., 2013,49, 2460-2462

Permissions

Request permissions

Light uncages a copper complex to induce nonapoptotic cell death

A. A. Kumbhar, A. T. Franks, R. J. Butcher and K. J. Franz, Chem. Commun., 2013, 49, 2460 DOI: 10.1039/C3CC38927H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements