Issue 37, 2011
From the journal:

Chemical Communications

cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands†‡

Cristina Airoldi,a   Francisco Cardona,ab   Erika Sironi,a   Laura Colombo,c   Mario Salmona,c   Artur Silva,b   Francesco Nicotraa  and  Barbara La Ferla*a  

* Corresponding authors

a Dept. of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126, Milan, Italy
E-mail: barbara.laferla@unimib.it
Fax: +39 0264483565
Tel: +39 0264483421

b Dept. of Chemistry, University of Aveiro, Campus Universitario de Santiago, 3810-193 Aveiro, Portugal

c Dept. of Molecular Biochemistry and Pharmacology Mario Negri Institute for Pharmacological Research, via La Masa 19, 20156, Milan, Italy

Abstract

A small library of glyco-fused benzopyran compounds has been synthesised. Their interaction features with Aβ peptides have been characterised by using STD-NMR and trNOESY experiments. The conformational analysis of the compounds has also been carried out through molecular mechanics (MM) and molecular dynamics (MD) simulations.

Graphical abstract: cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC13046C
Article type
Communication
Submitted
24 မေ 2011
Accepted
28 ဇူ 2011
First published
22 ဩ 2011

Chem. Commun., 2011,47, 10266-10268

Permissions

Request permissions

cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

C. Airoldi, F. Cardona, E. Sironi, L. Colombo, M. Salmona, A. Silva, F. Nicotra and B. La Ferla, Chem. Commun., 2011, 47, 10266 DOI: 10.1039/C1CC13046C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements