Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage

Gabriela J. Pedroso; Desirée M. S. Costa; Lucas T. Felipe Kokuszi; Eduardo B. V. da Silva; Marcos F. O. Cavalcante; Eduardo Junca; Cassio A. O. Moraes; Claus T. Pich; Vânia R. de Lima; Sumbal Saba; Jamal Rafique; Tiago E. A. Frizon

doi:10.1039/D2NJ04330K

Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage†

Gabriela J. Pedroso,^a Desirée M. S. Costa,^b Lucas T. Felipe Kokuszi,

^b Eduardo B. V. da Silva,^b Marcos F. O. Cavalcante,^c Eduardo Junca,^d Cassio A. O. Moraes,^e Claus T. Pich,

^a Vânia R. de Lima,^b Sumbal Saba,^c Jamal Rafique

*^ce and Tiago E. A. Frizon

*^a

Author affiliations

* Corresponding authors

^a Department of Energy and Sustainability, Federal University of Santa Catarina, Araranguá, SC, Brazil
E-mail: tiago.frizon@ufsc.br

^b Escola de Química e Alimentos, Programa de Pós-Graduação em Química Tecnológica e Ambiental, Universidade Federal do Rio Grande, RS, Brazil

^c Instituto de Química, Universidade Federal de Goiás, Goiânia, GO, Brazil

^d University of the Extreme South of Santa Catarina (UNESC), Criciúma, SC, Brazil

^e Institute of Chemistry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil
E-mail: jamal.rafique@ufms.br, jamal.chm@gmail.com
Web: https://sintmol.ufms.br/

Abstract

In this report, we evaluated the effects of selenylated indoles (3a–d) on lipid membranes and their capacity to interact with DNA. These selenylated indoles increased the motion rate of the polar region of lipids and compounds 3b–d ordered the non-polar region. The DNA cleavage ability was observed only for 3c.

This article is part of the themed collection: 50th anniversary of ICCST: celebrating ICCST at its 15th Edition

New Journal of Chemistry

Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage†

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Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage

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