We reproduce the human invention of the Chan–Lam reaction by predicting “unseen” reactions with “zero-shot reaction prediction”. We also mimics the later stage of the history of this reaction via “one-shot/few-shot reaction prediction” approaches.
Chan–Lam coupling has evolved as a shining star among C–heteroatom coupling reactions because of its greener open flask chemistry and tremendous possibilities in terms of substrate bank, catalyst varieties, unlocking nature friendly conditions, etc.
A base-free protocol for CuFe2O4 NP-catalysed, ultrasonic vibration-assisted Chan–Lam type C–N coupling reaction between amines and phenylboronic acid is reported.
The combination of copper and N,N′-dimethylurea is used to showcase the Chan–Lam N-arylation of three different nitrogen nucleophiles. The synthesized catalyst is cheap, chemoselective, and also found to be effective in the N-arylation of target APIs.
A concise Ru/Cu-catalyzed cascade providing rapid access to pyridazinoquinolinones and late-stage N-functionalization is reported.