The recent advances in trifluoroethylation reactions were summarized based on the bond formation: C(sp)–CH2CF3, C(sp2)–CH2CF3, C(sp3)–CH2CF3, and X (X = N, O, S, Se)–CH2CF3.
A highly efficient and chemoselective approach has been developed for the O- and S- trifluoroethylation of oxindoles, isoindolines, and thio-oxindoles utilizing Brønsted acid catalysis under greener protocol.
By virtue of light harvesting and proton transport of photoactive zinc–organic frameworks can be precisely regulated by the introduction of fluorine-containing moieties enabling them photocatalysts for photocatalytic selective trifluoroethylation.
We report a photo-nickel co-catalysed strategy to access a variety of trifluoroethyl heteroarenes. The synthetic value of this protocol was proved by its scalability in flow and application to the late-stage functionalization of drug-like molecules.
A photocatalytic route towards 2-trifluoroethylated and 2-perfluoroalkylated indoles is reported. This transition-metal-free protocol employs simple fluoroalkyl halide precursors and works under mild conditions.