Targeting Protein–Protein Interfaces with Peptides: The Contribution of Chemical Combinatorial Peptide Library Approaches

Alessandra Monti, Luigi Vitagliano, Andrea Caporale, Menotti Ruvo and Nunzianna Doti

IJMS, 2023, 24, 7842
DOI: 10.3390/ijms24097842

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

Liora S. Katz, Emira J. Visser, Kathrin F. Plitzko, Marloes A. M. Pennings, Peter J. Cossar, Isabelle L. Tse, Markus Kaiser, Luc Brunsveld, Christian Ottmann and Donald K. Scott

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-57241-7

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein–Protein Interaction as a Molecular Glue Drug Discovery Approach

Bente A. Somsen, Rick J.C. Schellekens, Carlo J.A. Verhoef, Michelle R. Arkin, Christian Ottmann, Peter J. Cossar and Luc Brunsveld

J. Am. Chem. Soc., 2023, 145, 6741
DOI: 10.1021/jacs.2c12781

A simple method for developing lysine targeted covalent protein reagents

Ronen Gabizon, Barr Tivon, Rambabu N. Reddi, Maxime C. M. van den Oetelaar, Hadar Amartely, Peter J. Cossar, Christian Ottmann and Nir London

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-42632-5

Exploring nondegrading molecular glues for protein–protein interactions

Sitong Yu, Lixin Zhou, Jing Yang, Jian Zhang and Wenchao Lu

Trends in Biochemical Sciences, 2025
DOI: 10.1016/j.tibs.2025.07.005

Recent Developments in 14–3–3 Stabilizers for Regulating Protein–Protein Interactions: An Update

Yucheng Tian, Longjing Li, Liuyi Wu, Qianqian Xu, Yaojie Li, Huawei Pan, Tiejun Bing, Xiumei Bai, Alexander V Finko, Zhiyu Li and Jinlei Bian

J. Med. Chem., 2025, 68, 2124
DOI: 10.1021/acs.jmedchem.4c01936

Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation

Janine Hochmair, Maxime C. M. van den Oetelaar, Leandre Ravatt, Lisa Diez, Lenne J. M. Lemmens, Renata Ponce-Lina, Rithika Sankar, Maximilian Franck, Gesa Nolte, Ekaterina Semenova, Satabdee Mohapatra, Christian Ottmann, Luc Brunsveld and Susanne Wegmann

Commun Biol, 2025, 8
DOI: 10.1038/s42003-025-08548-0