Three-component Friedel–Crafts-type difunctionalization of ynamides with (hetero)arenes and iodine(iii) electrophile

Jun Kikuchi, Toya Nagata, Shingo Ito and Naohiko Yoshikai

Org. Chem. Front., 2024, 11, 3072
DOI: 10.1039/D4QO00489B

An iodonium based cross-linking tool for tyrosine conjugation

Rihárd Sisa, János T. Csenki, Flavián Domány, Dóra Ágocsi-Kiss, Levente Dókus, Gábor Mező, Péter P. Fehér, András Stirling, Anna J. Kiss-Szemán and Zoltán Novák

Org. Chem. Front., 2026, 13, 2056
DOI: 10.1039/D5QO01572C

Recent developments in the cleavage, functionalization, and conjugation of proteins and peptides at tyrosine residues

Shengping Zhang, Luis M. De Leon Rodriguez, Freda F. Li and Margaret A. Brimble

Chem. Sci., 2023, 14, 7782
DOI: 10.1039/D3SC02543H

Toward a Traceless Tag for the Thiol‐Mediated Uptake of Proteins

John R. J. Maynard, Saidbakhrom Saidjalolov, Marie‐Claire Velluz, Stefania Vossio, Charlotte Aumeier, Dimitri Moreau, Naomi Sakai and Stefan Matile

ChemistryEurope, 2023, 1
DOI: 10.1002/ceur.202300029

Diverse tyrosine modification strategies in peptides/proteins and applications in radiopharmaceuticals

Quan Zuo, Junlong Lu, Zihan Huang, Zirui Zhang, Jie Yan, Guoqing Li, Siqi Zhang, Wangsheng Sun, Kuan Hu and Rui Wang

Coordination Chemistry Reviews, 2025, 540, 216765
DOI: 10.1016/j.ccr.2025.216765

Disintegrate (DIN) Theory Enabling Precision Engineering of Proteins

Preeti Chauhan, Ragendu V., Mohan Kumar, Rajib Molla, Unnikrishnan V. B. and Vishal Rai

ACS Cent. Sci., 2023, 9, 137
DOI: 10.1021/acscentsci.2c01455

Recent Advances in Bioorthogonal Ligation and Bioconjugation

Florian M. Zielke and Floris P. J. T. Rutjes

Top Curr Chem (Z), 2023, 381
DOI: 10.1007/s41061-023-00445-6

Peptide‐Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization**

Xing‐Yu Liu, Xinjian Ji, Christian Heinis and Jerome Waser

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202306036

Electrochemical Bioconjugation of Tryptophan Residues: A Strategy for Peptide Modification

Chenggang Wan, Rong Sun, Wenjie Xia, Haoyang Jiang, Bo-Xun Chen, Pei-Chi Kuo, Wan-Rou Zhang, Guichun Yang, Dingyu Li, Chien-Wei Chiang and Yue Weng

Org. Lett., 2024, 26, 5447
DOI: 10.1021/acs.orglett.4c01662

Site‐Selective Peptide and Protein Functionalization with Cyclopropenium Cations

Adriana Faraone, Matteo Balletti, Aliénor Jeandin, Hang‐Fei Tu, Viktoria A. Ikonnikova, Laura S. Sojka and Marcos G. Suero

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202518939

Water-Tolerant Iminium Reactive Species for Tyrosine-Specific Functionalization

Bivas Mondal, Lei Wang, Shirui Wang and Teck-Peng Loh

JACS Au, 2026, 6, 357
DOI: 10.1021/jacsau.5c01272

Methodology of stable peptide based on propargylated sulfonium

Heng Li, Zhanfeng Hou, Yuena Wang, Ziyuan Zhou, Jin Cai, Qilei Xin, Feng Yin, Zigang Li and Naihan Xu

Biochemistry and Biophysics Reports, 2023, 35, 101508
DOI: 10.1016/j.bbrep.2023.101508

Pd(I)-catalyzed ring-opening arylation of cyclopropyl-α-aminoamides: Access to α-ketoamide peptidomimetics

Yue Sun, Liming Yang, Yaohang Cheng, Guanghui An and Guangming Li

Chinese Chemical Letters, 2024, 35, 109250
DOI: 10.1016/j.cclet.2023.109250

Peptide‐Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization**

Xing‐Yu Liu, Xinjian Ji, Christian Heinis and Jerome Waser

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202306036

Mechanochemical Synthesis of X‐Vinylbenziodoxol(on)es and One‐Pot Conversion to Complex Alkenes**

Sayad Doobary, Judith Braunreuther, Andrew K. Inge and Berit Olofsson

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202519049

Research progress on chemical modifications of tyrosine residues in peptides and proteins

Wei Zeng, Jianyuan Xue, Haoxing Geng, Xia Liu, Jin Yang, Wei Shen, Yuqing Yuan, Yujie Qiang and Qing Zhu

Biotech & Bioengineering, 2024, 121, 799
DOI: 10.1002/bit.28622

Site‐Selective Peptide and Protein Functionalization with Cyclopropenium Cations

Adriana Faraone, Matteo Balletti, Aliénor Jeandin, Hang‐Fei Tu, Viktoria A. Ikonnikova, Laura S. Sojka and Marcos G. Suero

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202518939

Peptide/Protein Functionalization and Macrocyclization via Alkyne Umpolung with Hypervalent Iodine Reagents

Xing-Yu Liu and Jerome Waser

Acc. Chem. Res., 2025, 58, 2852
DOI: 10.1021/acs.accounts.5c00451

Nonperturbative Fluorogenic Labeling of Immunophilins Enables the Wash-free Detection of Immunosuppressants

Marco Bertolini, Lorena Mendive-Tapia, Ouldouz Ghashghaei, Abigail Reese, Charles Lochenie, Anna M. Schoepf, Miquel Sintes, Karolina Tokarczyk, Zandile Nare, Andrew D. Scott, Stephen R. Knight, Advait R. Aithal, Amit Sachdeva, Rodolfo Lavilla and Marc Vendrell

ACS Cent. Sci., 2024, 10, 969
DOI: 10.1021/acscentsci.3c01590

Silver-Catalyzed Coupling of Ethynylbenziodoxolones with CO2 and Amines to Afford O-β-Oxoalkyl Carbamates

Li Wei, Yanhui Guo, Ziyang Li, Huanfeng Jiang and Chaorong Qi

Org. Lett., 2024, 26, 4600
DOI: 10.1021/acs.orglett.4c01147

Structure-reactivity analysis of novel hypervalent iodine reagents in S-vinylation of thiols

Sayad Doobary, Ester Maria Di Tommaso, Alexandru Postole, A. Ken Inge and Berit Olofsson

Front. Chem., 2024, 12
DOI: 10.3389/fchem.2024.1376948

Metal Catalysis within Tyrosine Bioconjugation

Carlota Girón-Elola and Arkaitz Correa

Synlett, 2025
DOI: 10.1055/a-2759-6541

Exploring Chemical Modifications of Aromatic Amino Acid Residues in Peptides

Susanta Bhunia, Manasa Purushotham, Ganesh Karan, Bishwajit Paul and Modhu Sudan Maji

Synthesis, 2023, 55, 3701
DOI: 10.1055/a-2091-8062

Thermally Triggered Triazolinedione–Tyrosine Bioconjugation with Improved Chemo- and Site-Selectivity

Elias Denijs, Kamil Unal, Kevin Bevernaege, Sabah Kasmi, Bruno G. De Geest and Johan M. Winne

J. Am. Chem. Soc., 2024, 146, 12672
DOI: 10.1021/jacs.4c02173

Recent Progress in Synthetic Applications of Hypervalent Iodine(III) Reagents

Akira Yoshimura and Viktor V. Zhdankin

Chem. Rev., 2024, 124, 11108
DOI: 10.1021/acs.chemrev.4c00303

Stereoselective Approach to Multisubstituted Enolates from Unactivated Alkynes: Oxyalkylidenation of Alkynyl Ketone Enolates with Aldehydes

Shuma Sasaki, Jun Kikuchi, Shingo Ito and Naohiko Yoshikai

J. Org. Chem., 2023, 88, 14096
DOI: 10.1021/acs.joc.3c01615

Triazination/IEDDA Cascade Modular Strategy Installing Pyridines/Pyrimidines onto Tyrosine Enables Peptide Screening and Optimization

Quan Zuo, Xinyi Song, Jie Yan, Guangjun Bao, Yiping Li, Jieting Shen, Zeyuan He, Kuan Hu, Wangsheng Sun and Rui Wang

J. Am. Chem. Soc., 2025, 147, 9576
DOI: 10.1021/jacs.4c17615

Linker-Engineered Tyrosine–Azide Coatings for Stable Strain-Promoted Azide–Alkyne Cycloaddition (SPAAC) Functionalization

Suho Park, Himani Bisht, Jiwoo Park, Seongchul Park, Yubin Hong, Daeun Chu, Minseob Koh, Hojae Lee and Daewha Hong

Polymers, 2025, 17, 2969
DOI: 10.3390/polym17222969

Mechanochemical Synthesis of X‐Vinylbenziodoxol(on)es and One‐Pot Conversion to Complex Alkenes**

Sayad Doobary, Judith Braunreuther, Andrew K. Inge and Berit Olofsson

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202519049

Electrochemical selenylation of tyrosine oligopeptides to benzo[b]furan-functionalized peptides

Xinwei Hu, Yong Zeng, Jiongdong Ma, Han Diao, Fei-Xiao Chen, Mu Chen, Shou-Kun Zhang, Chengzhi Jin, Shao-Fei Ni and Zhixiong Ruan

Chinese Chemical Letters, 2026, 37, 111928
DOI: 10.1016/j.cclet.2025.111928

X‐Ray Visible Protein Scaffolds by Bulk Iodination

Carlos Flechas Becerra, Lady V. Barrios Silva, Ebtehal Ahmed, Joseph C. Bear, Zhiping Feng, David Y.S. Chau, Samuel G. Parker, Steve Halligan, Mark F. Lythgoe, Daniel J. Stuckey and P. Stephen Patrick

Advanced Science, 2024, 11
DOI: 10.1002/advs.202306246