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Food Funct., 2024, 15, 5714
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Stachydrine from Natural Foods Alleviates Hyperuricemia by Modulating Renal Urate Transporters and Suppressing Mitochondrial Oxidative Stress

Jian Guo, Jinhui Jia, Ailin Wang, Yunqi Gu and Xiaodong Xia

Foods, 2025, 14, 1718
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Comprehensive profiling of xanthine oxidase inhibitors of Changbaishan ganoderma and its treatment of Gout disease

Yang Zhou, Xuanlin Liu, Sainan Li, Chunming Liu, Yuchi Zhang and Ruijun Sun

Journal of Molecular Structure, 2025, 1340, 142446
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Pathophysiological Mechanisms of Hyperuricemia and the Therapeutic Potential of Food and Medicine Homologous Substances

Mengyao Liu, Xinwei Du, Shuya Yao, Baolong Zhao, Jinyuan Sun and Baoguo Sun

Adv. Funct. Foods, 2025, 1, 93
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A Comprehensive Review on Targeting Hyperuricemia with Edible Bioactive Polysaccharides: Advances in Structure, Xanthine Oxidase inhibition, Uric acid-Lowering Strategies, Mechanisms, and Current Applications

Zain Ullah, Zihao Yan, Min Zhang, Peng Liu, Panpan Yue, Ting Zhao, Liuqing Yang and Guangying Chen

Food Reviews International, 2025, 1
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Tinospora crispa (L.) Hook.f. & Thomson vines ameliorates hyperuricemia by inhibiting synthesis and promoting excretion of uric acid through targeting NLRP3/caspase-1/IL-1β pathway

Nuoshi Chen, Dandan Liu, Zelin He, Yuping Zhang, Yongzhi Lai, Shaoran Wang, Fei He, Ligang Jie and Hongyan Du

Journal of Ethnopharmacology, 2025, 340, 119271
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Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects

Yu Han, Wanlu Liu, Kexin Li, Mingzhen Zhang, Xinqi Liu, Lu Li, Zhao Guo and He Li

Foods, 2024, 14, 58
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Peptide NCTX15 derived from spider toxin gland effectively relieves hyperuricemia in mice

Yixiang Liu, Naixin Liu, Wenxin Bian, Yue Zhang, Yutong Wu, Ying Peng, Zeqiong Ru, Zhe Fu, Yinglei Wang, Chao Li, Xinwang Yang and Ying Wang

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Effects and mechanisms of Polygonati Rhizoma polysaccharide on potassium oxonate and hypoxanthine-induced hyperuricemia in mice

Nanxin Zhang, Bichen Zhang, Xiangjun Chen, Yingqiong Zhang, Yue Wang, Shuanghui Lu, Hengbin Zhang, Yujia Chen, Huidi Jiang and Hui Zhou

International Journal of Biological Macromolecules, 2024, 280, 135550
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Xin Sun, Le Yang, Hui Sun, Ye Sun, Shuyun Wei, Ying Han, Wenkai Wang, Ling Kong and Xijun Wang

Front. Pharmacol., 2023, 14
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Potential of probiotic-fermented Flos sophorae as a functional food: Enhanced anti-hyperuricemic activity and modulation of volatile components

Rui Cui, Cong Zhang, Zhen-Hui Pan, Teng-Gen Hu and Hong Wu

Food Bioscience, 2025, 63, 105640
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Innovative modeling: a diet-induced quail model for progressive pathological changes in uric acid metabolism disorders

Yi Xu, Yu Wang, Fujun Gao, Chengjin Lu, Shujia Liu, Siying Chen, Xiaomeng Zhang, Zhijian Lin and Bing Zhang

Front. Nutr., 2025, 12
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The role of dietary polysaccharides in uric acid regulation: Mechanisms and benefits in managing hyperuricemia

Wenchen Yu, Jiaren Liu, Denis Baranenko, Alejandro Cifuentes, Elena Ibañez, Yingchun Zhang and Weihong Lu

Trends in Food Science & Technology, 2025, 157, 104902
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A Systematic Review on the Research Progress on Polysaccharides from Fungal Traditional Chinese Medicine

Chenxi Bai, Fazhi Su, Wensen Zhang and Haixue Kuang

Molecules, 2023, 28, 6816
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Polysaccharide extracted from cultivated Sanghuangporous vaninii spores using three-phase partitioning with enzyme/ultrasound pretreatment: Physicochemical characteristics and its biological activity in vitro

Fuchun Jiang, Ruibing Chen, Chuanhong Tang, Long-Qing Li, Jing-Kun Yan and Henan Zhang

International Journal of Biological Macromolecules, 2023, 253, 126622
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Association of α-Klotho with anti-aging effects of Ganoderma lucidum in animal models

Xiaojing Liu, Jiamin Zhao, Jia Liu, Yan Huang, Wei Deng, Luwen Yan, Ming Cui, Xinhua Pan, Huiwen Xiao and Xingzhong Liu

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Ganoderic acids alleviate atherosclerosis by inhibiting macrophage M1 polarization via TLR4/MyD88/NF-κB signaling pathway

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Therapeutic potential of Ganoderma lucidum polysaccharide peptide in Doxorubicin-induced nephropathy: modulation of renin-angiotensin system and proteinuria

Hui Fang, Dongmei Lin, Xinxuan Li, Lianfu Wang and Teng Yang

Front. Pharmacol., 2023, 14
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Inhibition of intrarenal PRR-RAS pathway by Ganoderma lucidum polysaccharide peptides in proteinuric nephropathy

Hui Fang, Xinxuan Li, Dongmei Lin, Lianfu Wang, Teng Yang and Baoxue Yang

International Journal of Biological Macromolecules, 2023, 253, 127336
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Structural characterization and anti-hyperuricemic effect of a mannogalactan from Armillariella tabescens mycelium

Wenhua Guo, Junqiang Zhang, Hailan Deng, Yunbo Hao, Hao Chen, Yong Li, Wenna Zhang, Mei Zhang and Yan Chen

International Journal of Biological Macromolecules, 2024, 283, 137152
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Uric Acid‐Lowering and Anti‐Hyperuricemia Effects of Plant‐Based Nutraceuticals and Foods: A Review

Linwei He, Wenjian Yang and Jianhui Liu

Food Chemistry International, 2025, 1, 216
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Guluronate oligosaccharides exerts beneficial effects on hyperuricemia and regulation of gut microbiota in mice

Biqian Wei, Pengfei Ren, Changhu Xue, Yuming Wang and Qingjuan Tang

Food Bioscience, 2023, 54, 102855
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Signal pathways in the treatment of Rheumatoid Arthritis with traditional Chinese medicine

Siwei Wang, Jiamin Zhang, Wei Liu, Lei Zhang, Renhe Li, Yiwen Wang, Suiran Li, Le Li, Jianbin Li, Meijiao Zhou, Yuanhao Wu, Yuxiu Ka, Zhuo Tang and Wen Wang

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Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization

Zhijiao Zhang, Xiaoyu Shi, Ting Wu, Zhuhan He, Ruipeng Liang, Wenjie Ye, Zhenkun Wu, Hui Liao, Fengxin Zheng, Qian Yang, Zean Zhao, Yongjun Chen, Zhen Gao, Shuo Wang, Mei Wang, Zhenqian Wang, Danhui Qi, Mingyu Yang, Shujing Xu, Youzhao Wang, Tong Zhao, Javier Egea, Xinyong Liu, Jianxin Pang, Fan Yi and Peng Zhan

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A review of polysaccharides from Ganoderma lucidum: Preparation methods, structural characteristics, bioactivities, structure-activity relationships and potential applications

Maohui Yang, Xuemei Qin and Xiaojie Liu

International Journal of Biological Macromolecules, 2025, 303, 140645
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Structure, sources, functional mechanisms, and applications of bioactive glycopeptides in food: A comprehensive review

Dangfeng Wang, Benyou Zhang, Likun Ren, Yang Jiang, Yuqiong Meng, Rui Ma, Shulin Wang, Xuepeng Li, Fangchao Cui, Tingting Li and Jianrong Li

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Revisiting the metabolic crosstalk between type 2 diabetes and hyperuricemia: Pathophysiological insights and therapeutic perspectives

Xiuqiang Xia, Hongyu Niu, Changsong Xu, Xinghao Liu, Guoying Zhang and Jianya Ling

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2026, 1872, 168102
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Anti-hyperuricemia effects of a polysaccharide-protein complex from Lentinula edodes mediated by gut-kidney axis

Xinyi Xiong, Peng Liu, Liping Liu, Jie Feng, Jingsong Zhang, Mengqiu Yan and Yanfang Liu

International Journal of Biological Macromolecules, 2025, 293, 139370
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Uric acid metabolism regulation mechanism by probiotics and prebiotics: from a new perspective

Jiageng Cheng, Yuan Su, Yifan Wu, Longjiao Zhu, YanLin Chen, Shimin Chang, Kunlun Huang and Wentao Xu

Trends in Food Science & Technology, 2025, 161, 105076
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Identification of Hyperuricemia Alleviating Peptides from Yellow Tuna Thunnus albacares

Li Hao, Yulian Ding, Yan Fan, Qiaoji Tian, Yang Liu, Yueting Guo, Jian Zhang and Hu Hou

J. Agric. Food Chem., 2024, 72, 12083
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Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment

Jing-wen Guo, Guo-qiang Lin, Xin-yi Tang, Jia-ying Yao, Chen-guo Feng, Jian-ping Zuo and Shi-jun He

Acta Pharmacol Sin, 2025, 46, 1156
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Ganoderma lucidum polysaccharides: A comprehensive overview of pharmacological effects and future perspectives

Hui Fang, Shangpeng Yang and Teng Yang

Food Bioscience, 2025, 64, 105990
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Research progress on the prevention and treatment of hyperuricemia by medicinal and edible plants and its bioactive components

Wang Cheng-yuan and Dai Jian-gang

Front. Nutr., 2023, 10
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A novel spider-toxin-derived anti-gout peptide NCTX14 alleviated NLRP3-mediated pyroptosis in hyperuricemia

Naixin Liu, Yixiang Liu, Junyuan Wang, Yuliu Yang, Yujing Ding, Xiaohan Sun, Mengfan Ma, Xin Yu, Shaoyang Zhang, Jing Tang, Xinwang Yang and Ying Wang

Process Biochemistry, 2025, 157, 10
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Dietary Oligosaccharides Isolated from Coix Seed Mitigate Hyperuricemia through Modulation of Lipid Metabolites and Intestinal Homeostasis

Guozhen Wu, Hongjing Dong, Tao Li, Chuangchuang Wang, Yingjian Guo, Lanping Guo and Xiao Wang

J. Agric. Food Chem., 2025, 73, 4078
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Ganoderma lucidum Polysaccharide Peptide Alleviates Cyclophosphamide-Induced Male Reproductive Injury by Reducing Oxidative Stress and Apoptosis

Hang Zhang, Nannan Li, Yukun Zhang, Yue Xu, Feng Lu, Dongmei Lin, Shuqian Lin, Min Li and Baoxue Yang

Biomedicines, 2024, 12, 1632
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New insights into anti-hyperuricemic effects of novel peptides from Antarctic Krill (Euphausia superba) by Q-Exactive Orbitrap MS-based non-targeted metabolomics

Li Hao, Yulian Ding, Yan Fan, Chensi Xia, Yuqian Meng, Qiannan Jia, Jian Zhang, Changhu Xue and Hu Hou

Food Bioscience, 2024, 59, 104063
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Prediction and evaluation of purine-binding peptides using integrated molecular descriptors and docking analysis

Jun Zhong, Yongzhao Xu, Ganhong Xiao, Congcong Gong and Jiaoyan Ren

International Journal of Biological Macromolecules, 2025, 306, 141209
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Structural divergence of lentinula edodes polysaccharides is associated with distinct anti-hyperuricemia pathways

Xinyi Xiong, Peng Liu, Liping Liu, Jie Feng, Jingsong Zhang, Jinyan Wang, Jie Geng and Yanfang Liu

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Chinese Sumac (Rhus chinensis Mill.) Fruits Prevent Hyperuricemia and Uric Acid Nephropathy in Mice Fed a High-Purine Yeast Diet

Nan Ma, Shengbao Cai, Yilin Sun and Chuanqi Chu

Nutrients, 2024, 16, 184
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Genome-wide association studies and traditional Chinese medicine in hyperuricemia: current evidence and mechanistic insights

Le Yang, Jing Liu, Shengping Luo and Yihui Deng

Front. Pharmacol., 2026, 16
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Research progress in the extraction and purification, structural characteristics, pharmacological activities, structure-activity relationships, and applications from Alpinia oxyphylla Miq. polysaccharides

Xingyu Wang, Jingyuan Wang, Haizheng Bi, Zhaojiong Zhang, Mengru Zhang and Meng Wang

International Journal of Biological Macromolecules, 2025, 315, 144387
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Dual anti-hyperuricemic and anti-gout effects of novel peptides: Xanthine oxidase inhibition, digestive properties, and TLRs-NF-κB pathway suppression in cellular models

Li Hao, Qiaoji Tian, Shiqi Li, Tingting Yang and Hu Hou

Food Bioscience, 2025, 72, 107488
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Mechanisms Associated With Renal Injury in Hyperuricemia and Strategies for the Development of Natural Active Substances

Wanping Lv, Huixiang Chen, Pan Zhou, Aihua Du and Yu Lei

Int J of Rheum Dis, 2025, 28
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Screening and Identification of Multitarget Uric Acid-Lowering Peptides Derived from Rice Residue Protein and Analysis of Their Mechanisms

Xinjian Bi, Ruibo Huang, Tingmin Qu, Ying Wu, Hao Wu, Daichen Mu, Jian Hu, Juan Liao, Yanting Duan and Li Wen

J. Agric. Food Chem., 2025, 73, 16906
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A comprehensive review on recent xanthine oxidase inhibitors of dietary based bioactive substances for the treatment of hyperuricemia and gout: Molecular mechanisms and perspective

Zain Ullah, Panpan Yue, Guanghua Mao, Min Zhang, Peng Liu, Xiangyang Wu, Ting Zhao and Liuqing Yang

International Journal of Biological Macromolecules, 2024, 278, 134832
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Anti-Hyperuricemia Activity and Potential Mechanisms of Medicinal Mushroom Activity: A Review of Preclinical Studies

Chun-Hong Lai and Hui-Chen Lo

Int J Med Mushrooms, 2024, 26, 1
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Evaluating renal injury characteristics in different rat models of hyperuricemia and elucidating pathological molecular mechanisms via serum metabolomics

Mengwen Liu, Jing Shen, Xuanshi Chen, Tuerxunayi Dawuti and Hui Xiao

Front. Pharmacol., 2024, 15
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Ganoderma Lucidum polysaccharide peptide (GL-PP2): A potential therapeutic agent against sepsis-induced organ injury by modulating Nrf2/NF-κB pathways

Teng Yang, Hui Fang, Dongmei Lin, Shangpeng Yang, Hongjian Luo, Lianfu Wang and Baoxue Yang

International Journal of Biological Macromolecules, 2025, 285, 138378
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Harpadon nehereus Peptide FF4 alleviates hyperuricemia by regulating uric acid synthetase and transporters, as well as modulating the ROS/NLRP3 signaling pathway

Yang-na Huang, Hui-wen Zheng, Sheng-xiang Zhao, Zhan-ying Zhu, Yong-jie Long, Yue-wen Chen and Jing-jing Fu

Food Bioscience, 2025, 74, 107941
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Food-derived bioactive peptides with anti-hyperuricemic activity: A comprehensive review

Arshad Mehmood, Asra Iftikhar and Xiumin Chen

Food Chemistry, 2024, 451, 139444
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AI-Empowered Precision Intervention Strategy of Food and Drug Homologous Treatment for Hyperuricemia

Feng Wang, Yuneng Li, Yan Zhang, Xuebin Yin, Siyu Xing, Xijuan Yang, Chunhong Zhang, Danyang Li and Fengzhong Wang

Adv. Funct. Foods, 2026, 2, 1
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