Application of bioactive metal ions in the treatment of bone defects

Shaorong Li, Yutao Cui, He Liu, Yuhang Tian, Gan Wang, Yi Fan, Jingwei Wang, Dankai Wu and Yanbing Wang

J. Mater. Chem. B, 2022, 10, 9369
DOI: 10.1039/D2TB01684B

Chitosan-vancomycin hydrogel incorporated bone repair scaffold based on staggered orthogonal structure: a viable dually controlled drug delivery system

Xiaohan Gao, Zexian Xu, Shangbo Li, Lidi Cheng, Dian Xu, Li Li, Liqiang Chen, Yaoxiang Xu, Zijian Liu, Yanshan Liu and Jian Sun

RSC Adv., 2023, 13, 3759
DOI: 10.1039/D2RA07828G

Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions

Ziyi Han, Jingdi Xiong, Xiaohan Jin, Qinyue Dai, Mingyue Han, Hongkun Wu, Jiaojiao Yang, Haiqin Tang and Libang He

J. Mater. Chem. B, 2024, 12, 842
DOI: 10.1039/D3TB02069J

The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects

Meng Chen, Yang Li, Wen-Xiu Hou, Da-Yong Peng, Jing-Kun Li and Hao-Xuan Zhang

IJN, 2023, Volume 18, 1365
DOI: 10.2147/IJN.S397316

Phytic Acid-Gallium Network on a Polyimide Fiber Woven Fabric as an Artificial Ligament for Boosting Ligament–Bone Healing and Infection Treatment

En Xie, Jun Mei, Shangyu Xie, Zhitao Hu, Xiaowen Xi, Anqi Song, Bin Yao, Deqiang Wang, Jie Wei and Yunfei Niu

ACS Appl. Mater. Interfaces, 2024, 16, 40726
DOI: 10.1021/acsami.4c08621

Customized Additive Manufacturing in Bone Scaffolds—The Gateway to Precise Bone Defect Treatment

Juncen Zhou, Carmine Wang See, Sai Sreenivasamurthy and Donghui Zhu

Research, 2023, 6
DOI: 10.34133/research.0239

Ga-containing Ti alloy with improved osseointegration for bone regeneration: In vitro and in vivo studies

Fupeng Li, Jinbing Wang, Kai Huang, Yihao Liu, Yiqi Yang, Kai Yuan, Jian He, Chunjie Liu, Tao Yang, Deliang Zeng, Minjie Fan, Pengfei Zheng, Han Yang, Qingfeng Huang and Shengbing Yang

Composites Part B: Engineering, 2023, 256, 110643
DOI: 10.1016/j.compositesb.2023.110643

Rising role of 3D-printing in delivery of therapeutics for infectious disease

Anthony J. Kyser, Bassam Fotouh, Mohamed Y. Mahmoud and Hermann B. Frieboes

Journal of Controlled Release, 2024, 366, 349
DOI: 10.1016/j.jconrel.2023.12.051

Cancer Inhibition and In Vivo Osteointegration and Compatibility of Gallium-Doped Bioactive Glasses for Osteosarcoma Applications

Lucas Souza, Filipe V. Ferreira, Joao H. Lopes, Jose Angelo Camilli and Richard A. Martin

ACS Appl. Mater. Interfaces, 2022, 14, 45156
DOI: 10.1021/acsami.2c12102

Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

Kaavian Shariati, Meiwand Bedar, Kelly X. Huang, Shahrzad Moghadam, Sarah Mirzaie, Jonnby S. LaGuardia, Wei Chen, Youngnam Kang, Xiaoyan Ren and Justine C. Lee

Advanced Therapeutics, 2025, 8
DOI: 10.1002/adtp.202400296

Graphene oxide/gallium nanoderivative as a multifunctional modulator of osteoblastogenesis and osteoclastogenesis for the synergistic therapy of implant-related bone infection

Ying Yang, Min Li, Bixia Zhou, Xulei Jiang, Dou Zhang and Hang Luo

Bioactive Materials, 2023, 25, 594
DOI: 10.1016/j.bioactmat.2022.07.015

Advances and prospects of 3D printed antibacterial bone implants: A systematic review

Xin Liu, Sihan Lu, Tianlin Wang, Xiaohong Wang, Ke Yang and Huazhe Yang

Journal of Materials Science & Technology, 2024, 200, 227
DOI: 10.1016/j.jmst.2024.02.040

Degradation behavior, osteogenesis, and antimicrobial properties of Ga-coated ZK60 Mg alloys for medical implants

Lu Feng, Zhou Wu, Yang Huang, Lin Shen, Bo Qiao, Jiale Wu, Ning Wen, Jin Hu and Bin Deng

Journal of Magnesium and Alloys, 2025
DOI: 10.1016/j.jma.2025.01.024

Engineering injectable bone/bioadhesive grafts delivery system with self-healing properties for bone regeneration

Qingzu Liu, Bin Zhu, Huikai Yang, Chongyang Liu, Yurong Chen, Xiaoyu Wu, Wangling Duan, Luyao Feng, Binhui Wang, Liang Shao, Jianpeng Gao, Yazhong Bu, Hongjian Liu, Keya Mao and Jianheng Liu

Bioactive Materials, 2025, 54, 47
DOI: 10.1016/j.bioactmat.2025.07.049

Gallium and gallium compounds: New insights into the “Trojan horse” strategy in medical applications

Wenyue Sun, Manlin Qi, Shi Cheng, Chunyan Li, Biao Dong and Lin Wang

Materials & Design, 2023, 227, 111704
DOI: 10.1016/j.matdes.2023.111704

Programmable, biodegradable composite scaffolds with variable pore morphology for minimal invasive bone repair

Li Wang, Xianhong Zeng, Xiaohu Chen, Xiyang Zeng and Kun Luo

Composites Part A: Applied Science and Manufacturing, 2022, 162, 107130
DOI: 10.1016/j.compositesa.2022.107130

Self-assembling peptide hydrogel scaffold integrating stem cell-derived exosomes for infected bone defects

Haiyan Xu, Jing Feng, Ning Dai, Qiong Han, Bei Zhou, Guiyun Yang and Rui Hu

Journal of Biomaterials Science, Polymer Edition, 2024, 35, 1511
DOI: 10.1080/09205063.2024.2336316

Gallium-doped borosilicate bioactive glass modified bacterial cellulose functional dressing for infective wound

Haiyong Ao, Dongxue Zhang, Le Ma, Maohu Wang, Jiajia Zong, Xiaowei Xun, Xidong Wu, Mengxia Peng, Yaqiang Li and Zhenxing Li

International Journal of Biological Macromolecules, 2025, 331, 148448
DOI: 10.1016/j.ijbiomac.2025.148448

Emerging non-antibiotic strategies for implant-associated biofilm infections by reprogramming the dysregulated immune microenvironment

Yu Zhang, Zhuo Dai, Xiaoye Li, Ao He, Jingben Zheng, Meng Ding, Qiang Li, Yongbin Mou, Dongliang Yang, Weijun Xiu and Heng Dong

npj Biofilms Microbiomes, 2026, 12
DOI: 10.1038/s41522-025-00907-3

Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review

Yihan Wang, Shutao Zhang, Bin’en Nie, Xinhua Qu and Bing Yue

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.895288

Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation

David Piñera-Avellaneda, Judit Buxadera-Palomero, Maria-Pau Ginebra, Elisa Rupérez and José María Manero

Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1303313

Three-dimensional printing of medical devices and biomaterials with antimicrobial activity: A systematic review

Manoela Almeida Martins Mace, Camila Leites Reginatto, Rosane Michele Duarte Soares and Alexandre Meneghello Fuentefria

Bioprinting, 2024, 38, e00334
DOI: 10.1016/j.bprint.2024.e00334

Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties

Fatih Kurtuldu, Nurshen Mutlu, Aldo R. Boccaccini and Dušan Galusek

Bioactive Materials, 2022, 17, 125
DOI: 10.1016/j.bioactmat.2021.12.034

Additive Manufacturing of Bioactive Glass and Its Polymer Composites as Bone Tissue Engineering Scaffolds: A Review

Lizhe He, Jun Yin and Xiang Gao

Bioengineering, 2023, 10, 672
DOI: 10.3390/bioengineering10060672

Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulation

Bin Lv, Juntao Wu, Yuan Xiong, Xudong Xie, Ze Lin, Bobin Mi and Guohui Liu

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.1023231

Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

Yu Wang, Huaiyuan Zhang, Huifen Qiang, Meigui Li, Yili Cai, Xuan Zhou, Yanlong Xu, Zhenzhen Yan, Jinhua Dong, Yuan Gao, Chengye Pan, Xiaojing Yin, Jie Gao, Tinglin Zhang and Zuochong Yu

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202304060

3D-printed bone scaffolds containing graphene oxide/gallium nanocomposites for dual functions of anti-infection and osteogenesis differentiation

Huihui Zhao, Min Liu, Junzhe Wang, Zhisheng Long, Long Xiong and Guowen Qian

Surfaces and Interfaces, 2025, 57, 105770
DOI: 10.1016/j.surfin.2025.105770

Enhancing Osteogenesis and Mechanical Properties through Scaffold Design in 3D Printed Bone Substitutes

Xinyi Cao, Kexin Sun, Junyue Luo, Andi Chen, Qi Wan, Hongyi Zhou, Hongbo Zhou, Yuehua Liu and Xiaojing Chen

ACS Biomater. Sci. Eng., 2025, 11, 710
DOI: 10.1021/acsbiomaterials.4c01661

Black Phosphorus Nanosheet-Based Composite Biomaterials for the Enhanced Repair of Infectious Bone Defects

Wen Yin, Shouye Sun, Hongyuan Yao, Wenbo Li, Yutao Cui and Chuangang Peng

ACS Biomater. Sci. Eng., 2025, 11, 1317
DOI: 10.1021/acsbiomaterials.4c02263

Advancement of Gallium and Gallium-Based Compounds as Antimicrobial Agents

Fupeng Li, Fengxiang Liu, Kai Huang and Shengbing Yang

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.827960

Antioxidative and antibacterial gallium (III)-phenolic coating for enhanced osseointegration of titanium implants via pro-osteogenesis and inhibiting osteoclastogenesis

Kui Xu, Caiyun Mu, Chi Zhang, Sijie Deng, Shan Lin, Linlin Zheng, Weizhen Chen and Qiqing Zhang

Biomaterials, 2023, 301, 122268
DOI: 10.1016/j.biomaterials.2023.122268

Gallium‐Doped MXene Nanozymes Protect Liver Through Multi‐Death Pathway Blockade and Hepatocyte Regeneration

Xiaopeng Cai, Jingwen Deng, Liqing Wang, Junjie Su, Dongyi Xian, Yilang Yan, Xinyu Yang, Chuanbin Wu, Tingting Peng, Yuan Ding, Guilan Quan, Weilin Wang, Min Zhou and Chao Lu

Advanced Science, 2026, 13
DOI: 10.1002/advs.202509079

A dual functional Ti-Ga alloy: inhibiting biofilm formation and osteoclastogenesis differentiation via disturbing iron metabolism

Fupeng Li, Kai Huang, Jinbing Wang, Kai Yuan, Yiqi Yang, Yihao Liu, Xianhao Zhou, Keyu Kong, Tao Yang, Jian He, Chunjie Liu, Haiyong Ao, Fengxiang Liu, Qian Liu, Tingting Tang and Shengbing Yang

Biomater Res, 2023, 27
DOI: 10.1186/s40824-023-00362-1

Surface-modified electrospun poly-ε-caprolactone incorporating ZnO NPs and QK peptide to repair bone defect via osteogenesis, angiogenesis and antibacterial

Yu Chen, Junyan Liu, Zhongyu Dai, Hongkun Hu, Zhichen Liu and Wenbin Liu

Colloids and Surfaces B: Biointerfaces, 2025, 246, 114388
DOI: 10.1016/j.colsurfb.2024.114388

Kevin H. Mwangi, Yue Qu, Peilun Hu, Toshitatsu Nagayasu, Jia-Feng Liu and Xiumei Wang

npj Biofilms Microbiomes, 2025, 11
DOI: 10.1038/s41522-025-00724-8

Metal-doped silicate and phosphate glasses for antibacterial dental biomaterials

Haruaki Kitagawa, Tomoki Kohno, Fan Deng, Gabriela L Abe, Hirohiko Sakai, Yo-Shiuan Fan, Tingyi Wu, Jun-ichi Sasaki and Satoshi Imazato

Biomaterial Investigations in Dentistry, 2023, 10
DOI: 10.1080/26415275.2023.2284372

Osseointegration and Histological Picture of Titanium Silicon Gallium Alloy vs. Titanium Silicon Alloy and Pure Titanium

Mostafa Samir Al-Shaikhly and Hikmat Jameel Abdul-Baqi

Al-Rafidain J Med Sci, 2023, 5, 247
DOI: 10.54133/ajms.v5i.280